Center for Neuroscience, University of California, Davis, CA, USA.
Department of Psychology, University of California, Davis, CA, USA.
Nat Commun. 2023 May 23;14(1):2946. doi: 10.1038/s41467-023-35967-6.
Recent work in cognitive and systems neuroscience has suggested that the hippocampus might support planning, imagination, and navigation by forming cognitive maps that capture the abstract structure of physical spaces, tasks, and situations. Navigation involves disambiguating similar contexts, and the planning and execution of a sequence of decisions to reach a goal. Here, we examine hippocampal activity patterns in humans during a goal-directed navigation task to investigate how contextual and goal information are incorporated in the construction and execution of navigational plans. During planning, hippocampal pattern similarity is enhanced across routes that share a context and a goal. During navigation, we observe prospective activation in the hippocampus that reflects the retrieval of pattern information related to a key-decision point. These results suggest that, rather than simply representing overlapping associations or state transitions, hippocampal activity patterns are shaped by context and goals.
最近的认知和系统神经科学研究表明，海马体可能通过形成认知地图来支持规划、想象和导航，这些地图捕获物理空间、任务和情况的抽象结构。导航涉及消除相似语境的歧义，以及规划和执行一系列决策以达到目标。在这里，我们在人类进行目标导向的导航任务期间检查了海马体的活动模式，以研究上下文和目标信息如何被纳入导航计划的构建和执行中。在规划期间，共享上下文和目标的路线之间的海马体模式相似性增强。在导航期间，我们观察到海马体中的前瞻性激活，反映了与关键决策点相关的模式信息的检索。这些结果表明，海马体活动模式不是简单地表示重叠的关联或状态转换，而是受到上下文和目标的影响。
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