Seger Sarah, Kriegel Jennifer, Lega Brad, Ekstrom Arne
Neuroscience Interdisciplinary Program, University of Arizona, 1503 E. University Blvd., Tucson, AZ 85719.
Department of Neurosurgery, University of Texas Southwestern Medical School, Dallas, TX.
bioRxiv. 2024 Dec 6:2024.12.04.626897. doi: 10.1101/2024.12.04.626897.
Low frequency oscillations in the hippocampus emerge during by both spatial navigation and episodic memory function in humans. We have recently shown that in humans, memory-related processing is a stronger driver of low frequency oscillations than navigation. These findings and others support the idea that low-frequency oscillations are more strongly associated with a general memory function than with a specific role in spatial navigation. However, whether the low-frequency oscillations that support episodic memory and those during navigation could still share some similar functional roles remains unclear. In this study, patients undergoing intracranial electroencephalography (iEEG) monitoring performed a navigation task in which they navigated and performed internally directed route replay, similar to episodic memory. We trained a random forest classification model to use patterns in low-frequency power (2-12 Hz) to learn the position during navigation and subsequently used the same model to successfully decode position during mental simulation. We show that removal of background differences in power between navigation and mental simulation is critical to detecting the overlapping patterns. These results suggest that the low-frequency oscillations that emerge during navigation are more associated with a role in memory than specifically with a navigation related function.
人类海马体中的低频振荡在空间导航和情景记忆功能过程中都会出现。我们最近发现，在人类中，与记忆相关的处理过程比导航更能驱动低频振荡。这些发现以及其他研究结果支持了这样一种观点，即低频振荡与一般记忆功能的关联比与空间导航中的特定作用更强。然而，支持情景记忆的低频振荡与导航过程中的低频振荡是否仍可能共享一些相似的功能作用，目前尚不清楚。在这项研究中，接受颅内脑电图（iEEG）监测的患者执行了一项导航任务，在该任务中他们进行导航并执行类似于情景记忆的内部导向路线回放。我们训练了一个随机森林分类模型，利用低频功率（2 - 12赫兹）模式来学习导航过程中的位置，随后使用相同模型成功解码心理模拟过程中的位置。我们表明，消除导航和心理模拟之间功率的背景差异对于检测重叠模式至关重要。这些结果表明，导航过程中出现的低频振荡与记忆中的作用更相关，而不是与特定的导航相关功能相关。
