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Evolutionary characteristics of SARS-CoV-2 Omicron subvariants adapted to the host.

作者信息

Tang Haijun, Shao Yun, Huang Yi, Qiao Shigang, An Jianzhong, Yan Ruhong, Zhao Xin, Meng Fang, Du Xiaohong, Qin F Xiao-Feng

机构信息

Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College; Suzhou Institute of Systems Medicine, Suzhou, 215123, China.

Shengli Clinical Medical College, Fujian Medical University; Center for Experimental Research in Clinical Medicine, Fujian Provincial Hospital, Fuzhou, 350001, China.

出版信息

Signal Transduct Target Ther. 2023 May 23;8(1):211. doi: 10.1038/s41392-023-01449-w.


DOI:10.1038/s41392-023-01449-w
PMID:37221221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10204007/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/10205755/1a77868b424c/41392_2023_1449_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/10205755/1a77868b424c/41392_2023_1449_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/10205755/1a77868b424c/41392_2023_1449_Fig1_HTML.jpg

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[3]
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[4]
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本文引用的文献

[1]
Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2.

Cell Host Microbe. 2022-9-14

[2]
Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5.

Nature. 2022-8

[3]
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection.

Nature. 2022-8

[4]
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis.

Signal Transduct Target Ther. 2022-3-9

[5]
Omicron adopts a different strategy from Delta and other variants to adapt to host.

Signal Transduct Target Ther. 2022-2-10

[6]
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity.

Nature. 2022-3

[7]
SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo.

Nature. 2022-3

[8]
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron.

Nature. 2022-3

[9]
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells.

Emerg Microbes Infect. 2022-12

[10]
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.

Signal Transduct Target Ther. 2020-6-12

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