Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
Department of Oncology and Radiotherapy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.
Int J Mol Sci. 2022 Sep 4;23(17):10133. doi: 10.3390/ijms231710133.
Long non-coding RNAs (lncRNA) have recently been identified as key regulators of oxidative stress in several malignancies. The level of reactive oxygen species (ROS) must be constantly regulated to maintain cancer cell proliferation and chemoresistance and to prevent apoptosis. This review will discuss how lncRNAs alter the ROS level in cancer cells. We will first describe the role of lncRNAs in the nuclear factor like 2 (Nrf-2) coordinated antioxidant response of cancer cells. Secondly, we show how lncRNAs can promote the Warburg effect in cancer cells, thus shifting the cancer cell's "building blocks" towards molecules important in oxidative stress regulation. Lastly, we explain the role that lncRNAs play in ROS-induced cancer cell apoptosis and proliferation.
长链非编码 RNA（lncRNA）最近被鉴定为几种恶性肿瘤氧化应激的关键调节剂。活性氧（ROS）的水平必须不断调节，以维持癌细胞增殖和化疗耐药性，并防止细胞凋亡。本综述将讨论 lncRNA 如何改变癌细胞中的 ROS 水平。我们将首先描述 lncRNA 在核因子样 2（Nrf-2）协调的癌细胞抗氧化反应中的作用。其次，我们展示了 lncRNA 如何促进癌细胞的瓦博格效应，从而将癌细胞的“构建块”转向对氧化应激调节重要的分子。最后，我们解释了 lncRNA 在 ROS 诱导的癌细胞凋亡和增殖中所起的作用。
