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腹腔镜供体右后叶切除术与右半肝切除术在活体肝移植中的比较。

Comparison of pure laparoscopic donor right posterior sectionectomy versus right hemihepatectomy for living donor liver transplantation.

机构信息

Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

Liver Transpl. 2023 Nov 1;29(11):1199-1207. doi: 10.1097/LVT.0000000000000181. Epub 2023 May 25.

DOI:10.1097/LVT.0000000000000181
PMID:37222425
Abstract

The right posterior section (RPS) graft for living donor liver transplantation is an alternative graft in a live liver donor with insufficient remnant left lobe volume and portal vein anomaly. Although there have been some reports regarding pure laparoscopic donor right posterior sectionectomy (PLDRPS), no study has compared PLDRPS versus pure laparoscopic donor right hemihepatectomy (PLDRH). The aim of our study was to compare the surgical outcomes of PLDRPS versus PLDRH at centers achieving a complete transition from open to laparoscopic approach in liver donor surgery. From March 2019 to March 2022, a total of 351 living donor liver transplantations, including 16 and 335 donors who underwent PLDRPS and PLDRH, respectively, were included in the study. In the donor cohort, there were no significant differences in major complication (≥grade III) rate and comprehensive complication index between the PLDRPS versus PLDRH group (6.3% vs. 4.8%; p = 0.556 and 2.7 ± 8.6 vs.1.7 ± 6.4; p = 0.553). In the recipient cohort, there was a significant difference in major complication (≥grade III) rate (62.5% vs. 35.2%; p = 0.034) but no significant difference in comprehensive complication index (18.3 ± 14.9 vs. 15.2 ± 24.9; p = 0.623) between the PLDRPS and PLDRH groups. PLDRPS in live liver donors with portal vein anomaly and insufficient left lobe was technically feasible and safe with experienced surgeons. The PLDRPS group might be comparable with the PLDRH group based on the surgical outcomes of donors and recipients. However, in terms of recipient outcomes, more careful selection of donors of the RPS graft and further research in a large number of cases are necessary to evaluate the usefulness of PLDRPS.

摘要

右后叶(RPS)供肝移植是活体肝移植中一种针对左肝体积不足和门静脉异常的供肝者的替代供肝方式。虽然已经有一些关于纯腹腔镜右后叶供肝节段切除术(PLDRPS)的报道,但尚无研究比较 PLDRPS 与纯腹腔镜右半肝切除术(PLDRH)。本研究的目的是比较在完全从开腹手术过渡到腹腔镜手术的肝脏供体手术中心,PLDRPS 与 PLDRH 的手术结果。2019 年 3 月至 2022 年 3 月,共纳入 351 例活体肝移植患者,其中 16 例和 335 例供体分别接受了 PLDRPS 和 PLDRH。在供体组中,PLDRPS 与 PLDRH 组之间主要并发症(≥III 级)发生率和综合并发症指数无显著差异(6.3% vs. 4.8%;p=0.556 和 2.7±8.6 vs. 1.7±6.4;p=0.553)。在受体组中,PLDRPS 组的主要并发症(≥III 级)发生率(62.5% vs. 35.2%;p=0.034)显著高于 PLDRH 组,但综合并发症指数(18.3±14.9 vs. 15.2±24.9;p=0.623)无显著差异。对于门静脉异常和左肝体积不足的活体供肝者,经验丰富的外科医生行 PLDRPS 是可行且安全的。从供体和受体的手术结果来看,PLDRPS 组与 PLDRH 组可能具有可比性。然而,就受体结局而言,需要对 RPS 供肝的供体进行更仔细的选择,并在大量病例中进一步研究,以评估 PLDRPS 的实用性。

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引用本文的文献

1
Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition).《中国活体肝移植供体微创肝切除术指南(2024年版)》
Hepatobiliary Surg Nutr. 2024 Dec 1;13(6):919-936. doi: 10.21037/hbsn-24-329. Epub 2024 Nov 20.