School of Medicine, Tsinghua University, Beijing, China.
Adv Exp Med Biol. 2023;1417:141-157. doi: 10.1007/978-981-99-1304-6_10.
Hepatitis E virus (HEV) infects over 20 million people worldwide per year, leading to 30,000-40,000 deaths. In most cases HEV infection in a self-limited, acute illness. However, chronic infections could occur in immunocompromised individuals. Due to scarcity of robust cell culture models in vitro and genetic tractable animal models in vivo, the details of HEV life cycle, as well as its interaction with host cells still remain elusive, which dampens antivirals discovery. In this chapter, we present an update in the HEV infectious cycle steps: entry, genome replication/subgenomic RNA transcription, assembly, and release. Moreover, we discussed the future prospective on HEV research and illustrates important questions urgently to be addressed.
戊型肝炎病毒（HEV）每年在全球感染超过 2000 万人，导致 3 万至 4 万人死亡。在大多数情况下，HEV 感染是一种自限性的急性疾病。然而，免疫功能低下的个体可能会发生慢性感染。由于缺乏体外强大的细胞培养模型和体内遗传上可操作的动物模型，HEV 生命周期的细节及其与宿主细胞的相互作用仍然难以捉摸，这阻碍了抗病毒药物的发现。在本章中，我们介绍了 HEV 感染周期步骤的最新进展：进入、基因组复制/亚基因组 RNA 转录、组装和释放。此外，我们讨论了 HEV 研究的未来前景，并说明了急需解决的重要问题。
