Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing 210095, China.
The Centre for Infection and Immunity Studies, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Cell. 2022 Mar 31;185(7):1117-1129.e8. doi: 10.1016/j.cell.2022.02.014. Epub 2022 Feb 16.
Game animals are wildlife species traded and consumed as food and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1,941 game animals, representing 18 species and five mammalian orders, sampled across China. From this, we identified 102 mammalian-infecting viruses, with 65 described for the first time. Twenty-one viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high-risk viruses. We inferred the transmission of bat-associated coronavirus from bats to civets, as well as cross-species jumps of coronaviruses from bats to hedgehogs, from birds to porcupines, and from dogs to raccoon dogs. Of note, we identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.
食用野生动物是被交易和消费的野生动物物种，它们是 SARS-CoV 和 SARS-CoV-2 的潜在宿主。我们对来自中国各地的 18 个物种和五个哺乳动物目共 1941 只野生动物进行了元转录组分析。从中，我们鉴定了 102 种感染哺乳动物的病毒，其中 65 种是首次描述的。21 种病毒被认为对人类和家畜有潜在的高风险。果子狸（Paguma larvata）携带的高风险病毒数量最多。我们推断出蝙蝠相关冠状病毒从蝙蝠传播到果子狸，以及冠状病毒从蝙蝠到刺猬、从鸟类到豪猪、从狗到貉的跨物种跳跃。值得注意的是，我们在果子狸和亚洲獾中发现了 H9N2 禽流感病毒，后者出现了呼吸道症状，还有可能发生人类到野生动物的病毒传播。这些数据强调了野生动物作为疾病出现的潜在驱动因素的重要性。
