Al-Moussa M, Beck J S
J Clin Pathol. 1986 May;39(5):483-8. doi: 10.1136/jcp.39.5.483.
Histometric measurements were made on individual nodules and the internodular thyroid on glands from 15 patients without evidence of endocrine thyroid disease: some of the thyroids had multiple nodules. Measurements of the surviving internodular thyroid tissue showed that the various components were each within the normal range for thyroids from patients with no evidence of thyroid disease, but there were considerable deviations within a few glands in the colloid:epithelium ratio that were associated with histological appearances of dilated or collapsed acini. The interpretation of these appearances presented difficulties, but it was concluded that the balance of evidence favoured the inference that the internodular part of the gland was under physiological growth control at the time of study. The nodules varied in size: most contained proportionately less epithelium and more colloid than the internodular thyroid. It was concluded that the nodules were unlikely to be secreting autonomously in these patients.
对15例无内分泌甲状腺疾病证据患者的腺体中的单个结节及结节间甲状腺组织进行了组织计量学测量：部分甲状腺有多个结节。对存活的结节间甲状腺组织的测量显示，各组成部分均在无甲状腺疾病证据患者甲状腺的正常范围内，但少数腺体的胶体与上皮细胞比例存在相当大的偏差，这与扩张或塌陷腺泡的组织学表现相关。对这些表现的解读存在困难，但得出的结论是，证据的平衡支持这样的推断，即在研究时腺体的结节间部分处于生理生长控制之下。结节大小各异：大多数结节的上皮细胞比例比结节间甲状腺组织少，胶体比例更高。得出的结论是，在这些患者中，结节不太可能自主分泌。
