Martin V, Martin L, Viennet G, Challier B, Carbillet J, Fellmann D
Laboratoire d'Histologie, CNRS UPRESA 6025, Faculté de Médecine et de Pharmacie, 2, place Saint-Jacques, 25030 Besançon Cedex.
Ann Pathol. 2000 May;20(3):196-201.
Solid Cell Nests (SCN) of the thyroid gland were considered as embryonic remnants or as squamous metaplasia of follicular epithelium. In a retrospective study of 1 390 thyroids, SCN were found in 9.7 % of thyroids (16 % men and 8 % women, chi(2) : p <0, 01). The number of SCN rises with increasing number of sections examined. No statistical differences were found with age or thyroid disorders and presence of SCN, excluding the metaplastic theory. SCN contained in 38 % of cases, neuroendocrine cells (calcitonin and/or calcitonin gene related peptide, chromogranin A) and thyroglobulin cells was observed in 78.3 % of SCN. The different cell types of SCN fitted with the ultimobranchial remnant theory. Thus, some rare carcinomas (like mixed medullary and vesicular carcinoma or mucoepidermoid carcinoma) might originate from SCN.
甲状腺的实性细胞巢（SCN）曾被认为是胚胎残余物或滤泡上皮的鳞状化生。在一项对1390个甲状腺的回顾性研究中，9.7%的甲状腺中发现了SCN（男性为16%，女性为8%，卡方检验：p<0.01）。SCN的数量随着检查切片数量的增加而增多。除化生理论外，未发现年龄、甲状腺疾病与SCN的存在之间存在统计学差异。在38%的病例中，SCN含有神经内分泌细胞（降钙素和/或降钙素基因相关肽、嗜铬粒蛋白A），78.3%的SCN中观察到甲状腺球蛋白细胞。SCN的不同细胞类型符合终末鳃体残余理论。因此，一些罕见的癌（如混合性髓样和泡状癌或黏液表皮样癌）可能起源于SCN。
