Mitchell C J, Jewell D P, Lewin M R, McLaughlin J E, Moorhead J F
J Clin Pathol. 1979 Mar;32(3):208-13. doi: 10.1136/jcp.32.3.208.
Gastric function and histology were investigated in 24 patients with untreated chronic renal failure. At endoscopy nine patients had oesophagitis, 12 patients were considered to have gastritis, and the duodenum appeared inflamed in 20 patients. Endoscopic biopsies were taken at standard sites in the stomach and duodenum; gastritis was found in all patients, and 17 patients had duodenitis. Stimulated acid secretion was impaired in seven out of 20 patients and acid hypersecretion was found in a further two patients. Pepsin output correlated well with acid output in these patients. Fasting serum gastrin levels were elevated in 12 of the 19 patients tested. Patients with atrophic gastritis had low acid outputs and hypergastrinaemia, and when extensive gastritis was present, the patients tended to have more severe renal failure and hyposecretion of acid. Three patients were studied again after regular haemodialysis or renal transplantation and were found to show marked endoscopic and histological improvement.
对24例未经治疗的慢性肾衰竭患者的胃功能和组织学进行了研究。内镜检查时，9例患者有食管炎，12例患者被认为有胃炎，20例患者十二指肠有炎症。在胃和十二指肠的标准部位取内镜活检；所有患者均发现有胃炎，17例患者有十二指肠炎。20例患者中有7例刺激胃酸分泌受损，另有2例患者胃酸分泌过多。这些患者的胃蛋白酶分泌量与胃酸分泌量密切相关。19例接受检测的患者中有12例空腹血清胃泌素水平升高。萎缩性胃炎患者胃酸分泌量低且有高胃泌素血症，当存在广泛胃炎时，患者往往有更严重的肾衰竭和胃酸分泌不足。3例患者在定期血液透析或肾移植后再次接受研究，发现内镜和组织学有明显改善。
