Wee A, Kang J Y, Ho M S, Choong H L, Wu A Y, Sutherland I H
Department of Pathology, National University Hospital, Singapore.
Gut. 1990 Oct;31(10):1093-6. doi: 10.1136/gut.31.10.1093.
This study aimed to determine the prevalence of endoscopic and histological gastroduodenitis as well as helicobacter-like organisms in patients with end stage renal failure undergoing maintenance dialysis treatment. A total of 322 out of 422 patients in our dialysis programme underwent endoscopy and gastroduodenal biopsy specimens were taken from 260. Endoscopic gastroduodenitis occurred in 158 (49%). Histological gastritis occurred in the gastric body or antrum in 134 patients (52%) and duodenitis in 52 (21%). There was no correlation between endoscopic and histological gastritis in contrast to a significant correlation for duodenitis. Helicobacter-like organisms occurred in the body or antrum in 81 (31%). Their presence was associated with gastritis--in particular acute and acute on chronic gastritis rather than chronic gastritis. Patients with gastritis were significantly older than those without (p less than 0.001) and had lower basal and peak acid outputs.
本研究旨在确定接受维持性透析治疗的终末期肾衰竭患者内镜下和组织学上胃十二指肠炎症以及类幽门螺杆菌的患病率。我们透析项目中的422名患者中，共有322名接受了内镜检查，并从260名患者中获取了胃十二指肠活检标本。内镜下胃十二指肠炎症发生在158例（49%）。组织学胃炎发生在胃体或胃窦的有134例患者（52%），十二指肠炎症发生在52例（21%）。内镜下胃炎与组织学胃炎之间无相关性，而十二指肠炎症则存在显著相关性。类幽门螺杆菌出现在胃体或胃窦的有81例（31%）。它们的存在与胃炎相关——尤其是急性胃炎以及慢性胃炎急性发作，而非慢性胃炎。患有胃炎的患者比未患胃炎的患者年龄显著更大（p<0.001），且基础胃酸分泌量和高峰胃酸分泌量更低。
