Kullaa-Mikkonen A
J Cutan Pathol. 1986 Apr;13(2):154-62. doi: 10.1111/j.1600-0560.1986.tb01516.x.
In this study, scanning electron microscopy (SEM) was used to describe in detail the surface structure of geographic tongue. Tissue samples from the anterior part of the tongue were removed from 15 patients with geographic tongue and from 15 control subjects. Normally, the surface mucosa of the tongue was covered by filiform papillae, which consisted of the body and hairs. The mucosal surface of the body was smooth with some desquamating cells, but hairs were covered by an extensive plaque of microorganism. With SEM, the surface of geographic tongue contained 3 different types of mucosa: atrophic area, white margin, and area of normal appearance. On the atrophic area, the mucosa formed low elevations, and hairs were lacking. At high magnification, the superficial cells of the low elevations were polygonal, and they had parallel or branching microplicae. The white margin contained many desquamating cells, which had broken microplicae or no surface structures. Here the inflammatory infiltrate of the epithelium and that of the subepithelial connective tissue was moderate. On the normal-appearing area, desquamation of the mucosa on the papillar bodies was more pronounced than normally. On every specimen was a fissure, on the walls of which the superficial cells had broken microplicae and knob-like structures. The adherence of candidal hyphae within the superficial cells was seen in the area of the fissure. On the geographic tongue some fungiform papillae with taste pores were seen.
在本研究中，使用扫描电子显微镜（SEM）详细描述了地图舌的表面结构。从15名地图舌患者和15名对照受试者的舌前部采集组织样本。正常情况下，舌的表面黏膜被丝状乳头覆盖，丝状乳头由主体和毛发状部分组成。主体的黏膜表面光滑，有一些脱落细胞，但毛发状部分被大量微生物菌斑覆盖。通过扫描电子显微镜观察，地图舌的表面包含3种不同类型的黏膜：萎缩区、白色边缘和外观正常区域。在萎缩区，黏膜形成低隆起，且没有毛发状部分。在高倍放大下，低隆起处的表层细胞呈多边形，有平行或分支的微褶。白色边缘含有许多脱落细胞，这些细胞的微褶已断裂或没有表面结构。此处上皮和上皮下结缔组织的炎性浸润中等。在外观正常区域，乳头体上黏膜的脱屑比正常情况更明显。每个标本上都有一条裂隙，裂隙壁上的表层细胞有断裂的微褶和瘤状结构。在裂隙区域可见念珠菌菌丝附着在表层细胞内。在地图舌上可见一些有味孔的菌状乳头。
