Department of Food Regulatory Science, Korea University, Sejong, Korea 30019.
Department of Food and Biotechnology, Korea University, Sejong, Korea 30019; BK21 FOUR Research Education Team for Omics-based Bio-Health in Food Industry, Korea University, Sejong 30019, Korea.
J Dairy Sci. 2023 Jul;106(7):4489-4501. doi: 10.3168/jds.2022-22762. Epub 2023 May 22.
This meta-analysis aimed to investigate the effect of probiotic administration on adults with lactose intolerance. Twelve studies were identified from databases such as PubMed, Cochrane Library, and Web of Knowledge based on the inclusion and exclusion criteria. The effect size was estimated using the standardized mean difference (SMD), and Cochrane's Q test was used to evaluate the statistical heterogeneity of the effect size. Moderator analysis, including meta-ANOVA and meta-regression, were performed to determine the cause of heterogeneity in the effect size using a mixed-effect model. Egger's linear regression test was conducted to evaluate publication bias. The results showed that probiotic administration alleviated the symptoms of lactose intolerance, including abdominal pain, diarrhea, and flatulence. Among them, the area under the curve (AUC) showed the greatest decrease following probiotic administration (SMD, -4.96; 95% confidence interval, -6.92 to -3.00). In the meta-ANOVA test, abdominal pain and total symptoms decreased with monostrain probiotic administration. This combination was also effective for flatulence. The dosage of probiotics or lactose was significantly associated with a reduction in the total symptom score, and the linear regression models between the dosage and SMD were found to be Y = 2.3342 × dosage - 25.0400 (R = 79.68%) and Y = 0.2345 × dosage - 7.6618 (R = 34.03%), respectively. Publication bias was detected for most items. However, even after effect size correction, the probiotic administration effect for all items remained valid. The administration of probiotics was effective at improving adult lactose intolerance, and it is expected that the results of this study could help improve the nutritional status of adults by increasing their consumption of milk and dairy products in the future.
本荟萃分析旨在研究益生菌给药对乳糖不耐受成人的影响。根据纳入和排除标准，从 PubMed、Cochrane 图书馆和 Web of Knowledge 等数据库中确定了 12 项研究。使用标准化均数差（SMD）估计效应大小，并使用 Cochrane's Q 检验评估效应大小的统计学异质性。使用混合效应模型进行调节分析，包括 meta-ANOVA 和 meta-回归，以确定效应大小异质性的原因。使用 Egger 的线性回归检验评估发表偏倚。结果表明，益生菌给药缓解了乳糖不耐受的症状，包括腹痛、腹泻和腹胀。其中，曲线下面积（AUC）显示益生菌给药后下降最大（SMD，-4.96；95%置信区间，-6.92 至-3.00）。在 meta-ANOVA 检验中，腹痛和总症状随着单株益生菌给药而减少。这种组合对腹胀也有效。益生菌剂量或乳糖量与总症状评分的降低显著相关，并且在剂量和 SMD 之间发现线性回归模型为 Y = 2.3342 × 剂量 - 25.0400（R = 79.68%）和 Y = 0.2345 × 剂量 - 7.6618（R = 34.03%）。大多数项目都检测到发表偏倚。然而，即使在对效应大小进行校正后，所有项目的益生菌给药效果仍然有效。益生菌给药对改善成人乳糖不耐受有效，预计本研究的结果未来可以通过增加成人对牛奶和乳制品的消费来帮助改善其营养状况。
