Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
J Obstet Gynaecol Res. 2023 Aug;49(8):2023-2030. doi: 10.1111/jog.15680. Epub 2023 May 24.
The human endometrium is a dynamically remodeling tissue that undergoes more than 400 cycles of regeneration, differentiation, shedding, and rapid healing during a woman's reproductive years. The endometrium is also the origin of various gynecologic diseases, such as endometriosis, adenomyosis, and uterine corpus cancer. Cancer-associated gene mutations are detected in endometriosis, adenomyosis, and normal endometrium. Some reports have demonstrated that the accumulation of genomic alterations is a critical carcinogenic mechanism in the progression from normal endometrium to ovarian clear cell carcinoma via endometriosis. In this review, we discuss the clinical importance of genomic alterations in the normal endometrium, contributing to the elucidation of the pathogenesis of endometrium-related diseases.
人类子宫内膜是一种动态重塑的组织，在女性生育期经历了超过 400 次的再生、分化、脱落和快速愈合循环。子宫内膜也是各种妇科疾病的起源，如子宫内膜异位症、子宫腺肌病和子宫体癌。在子宫内膜异位症、子宫腺肌病和正常子宫内膜中都检测到了与癌症相关的基因突变。一些报道表明，基因组改变的积累是从正常子宫内膜通过子宫内膜异位症进展为卵巢透明细胞癌的关键致癌机制。在这篇综述中，我们讨论了基因组改变在正常子宫内膜中的临床重要性，有助于阐明与子宫内膜相关疾病的发病机制。
