Son Jun Hyuk
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Korean J Gastroenterol. 2023 May 25;81(5):197-202. doi: 10.4166/kjg.2023.038.
Gallbladder polyps are a common incidental finding. Although most of these are benign, differentiating non-neoplastic from neoplastic polyps is challenging. Trans-abdominal ultrasound is the primary imaging study for diagnosing and monitoring gallbladder polyps. In challenging cases, the use of endoscopic ultrasound or contrast-enhanced endoscopic ultrasound could assist in making decisions. According to current guidelines, a cholecystectomy is recommended in patients with polyps measuring 10 mm or larger and in symptomatic patients with polyps measuring less than 10 mm. A cholecystectomy is also recommended if one or more risk factors for malignancy are present in patients with polyps measuring 6-9 mm. These risk factors include age older than 60 years, primary sclerosing cholangitis, Asian ethnicity, and sessile polyps, including focal gallbladder wall thickening >4 mm. Follow-up ultrasound is recommended at six months, one year, and two years for polyps measuring 6-9 mm in patients without risk factors for malignancy, and for polyps less than 5 mm in patients with one or more risk factors for malignancy. Discontinuing the surveillance could be considered in the absence of growth. Follow-up is not required for polyps measuring less than 5 mm in patients without the risk factors for a malignancy. On the other hand, the evidence for the guidelines is still lacking and of low quality. The management of gallbladder polyps should be individualized based on the currently available guidelines.
胆囊息肉是一种常见的偶然发现。虽然其中大多数是良性的,但区分非肿瘤性息肉和肿瘤性息肉具有挑战性。经腹超声是诊断和监测胆囊息肉的主要影像学检查。在疑难病例中,使用内镜超声或对比增强内镜超声有助于做出决策。根据当前指南,对于息肉直径达10毫米或更大的患者以及息肉直径小于10毫米的有症状患者,建议行胆囊切除术。对于息肉直径为6 - 9毫米且存在一个或多个恶性风险因素的患者,也建议行胆囊切除术。这些风险因素包括年龄大于60岁、原发性硬化性胆管炎、亚洲人种以及无蒂息肉,包括胆囊壁局限性增厚>4毫米。对于无恶性风险因素的息肉直径为6 - 9毫米的患者,以及有一个或多个恶性风险因素的息肉直径小于5毫米的患者,建议在6个月、1年和2年时进行超声随访。如果息肉没有生长,可以考虑停止监测。对于无恶性风险因素的息肉直径小于5毫米的患者,无需进行随访。另一方面,这些指南的证据仍然不足且质量较低。胆囊息肉的管理应根据当前可用指南进行个体化。