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[胆囊息肉管理与随访的最新进展]

[Recent Updates on Management and Follow-up of Gallbladder Polyps].

作者信息

Son Jun Hyuk

机构信息

Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

出版信息

Korean J Gastroenterol. 2023 May 25;81(5):197-202. doi: 10.4166/kjg.2023.038.

DOI:10.4166/kjg.2023.038
PMID:37226819
Abstract

Gallbladder polyps are a common incidental finding. Although most of these are benign, differentiating non-neoplastic from neoplastic polyps is challenging. Trans-abdominal ultrasound is the primary imaging study for diagnosing and monitoring gallbladder polyps. In challenging cases, the use of endoscopic ultrasound or contrast-enhanced endoscopic ultrasound could assist in making decisions. According to current guidelines, a cholecystectomy is recommended in patients with polyps measuring 10 mm or larger and in symptomatic patients with polyps measuring less than 10 mm. A cholecystectomy is also recommended if one or more risk factors for malignancy are present in patients with polyps measuring 6-9 mm. These risk factors include age older than 60 years, primary sclerosing cholangitis, Asian ethnicity, and sessile polyps, including focal gallbladder wall thickening >4 mm. Follow-up ultrasound is recommended at six months, one year, and two years for polyps measuring 6-9 mm in patients without risk factors for malignancy, and for polyps less than 5 mm in patients with one or more risk factors for malignancy. Discontinuing the surveillance could be considered in the absence of growth. Follow-up is not required for polyps measuring less than 5 mm in patients without the risk factors for a malignancy. On the other hand, the evidence for the guidelines is still lacking and of low quality. The management of gallbladder polyps should be individualized based on the currently available guidelines.

摘要

胆囊息肉是一种常见的偶然发现。虽然其中大多数是良性的,但区分非肿瘤性息肉和肿瘤性息肉具有挑战性。经腹超声是诊断和监测胆囊息肉的主要影像学检查。在疑难病例中,使用内镜超声或对比增强内镜超声有助于做出决策。根据当前指南,对于息肉直径达10毫米或更大的患者以及息肉直径小于10毫米的有症状患者,建议行胆囊切除术。对于息肉直径为6 - 9毫米且存在一个或多个恶性风险因素的患者,也建议行胆囊切除术。这些风险因素包括年龄大于60岁、原发性硬化性胆管炎、亚洲人种以及无蒂息肉,包括胆囊壁局限性增厚>4毫米。对于无恶性风险因素的息肉直径为6 - 9毫米的患者,以及有一个或多个恶性风险因素的息肉直径小于5毫米的患者,建议在6个月、1年和2年时进行超声随访。如果息肉没有生长,可以考虑停止监测。对于无恶性风险因素的息肉直径小于5毫米的患者,无需进行随访。另一方面,这些指南的证据仍然不足且质量较低。胆囊息肉的管理应根据当前可用指南进行个体化。

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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm.建立基于超声造影的影像组学模型用于术前预测直径大于10毫米的胆囊息肉样病变。
Eur J Med Res. 2025 Feb 3;30(1):66. doi: 10.1186/s40001-025-02292-1.
2
Establishing a preoperative predictive model for gallbladder adenoma and cholesterol polyps based on machine learning: a multicentre retrospective study.基于机器学习建立胆囊腺瘤和胆固醇息肉的术前预测模型:一项多中心回顾性研究。
World J Surg Oncol. 2025 Jan 28;23(1):27. doi: 10.1186/s12957-025-03671-y.
3
Investigating causal links between gallstones, cholecystectomy, and 33 site-specific cancers: a Mendelian randomization post-meta-analysis study.
探讨胆囊结石、胆囊切除术与 33 个特定部位癌症之间因果关系的孟德尔随机化后Meta 分析研究。
BMC Cancer. 2024 Sep 27;24(1):1192. doi: 10.1186/s12885-024-12906-2.
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Current considerations for the surgical management of gallbladder adenomas.胆囊腺瘤外科治疗的当前考量因素。
World J Gastrointest Surg. 2024 Jun 27;16(6):1507-1512. doi: 10.4240/wjgs.v16.i6.1507.