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失眠症中助眠药物的使用:时间监测行为的作用。

Use of Sleep Aids in Insomnia: The Role of Time Monitoring Behavior.

机构信息

Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.

Sleep and Human Health Institute, Savannah, Georgia.

出版信息

Prim Care Companion CNS Disord. 2023 May 16;25(3):22m03344. doi: 10.4088/PCC.22m03344.

Abstract

Over-the-counter (OTC) and prescription sleep medications are frequently used as treatments for chronic insomnia, despite risks and limited long-term efficacy. Investigating mechanisms underlying this predilection for pharmacotherapy may uncover strategies to decrease reliance on sleep aids. The objective of this study was to determine how time monitoring behavior (TMB; clock-watching) and associated frustration may interact with insomnia symptoms to drive the use of sleep aids. Patients (N = 4,886) presenting for care at a community-based, private sleep medical center between May 2003 and October 2013 completed the Insomnia Severity Index (ISI) and Time Monitoring Behavior-10 (TMB-10) and reported their frequency of sleep medication use (OTC and prescription, separately). Mediation analyses examined how clock-watching and related frustration could be associated with insomnia symptoms and medication use. The relationship between TMB and sleep medication use was significantly explained by ISI ( < .05), in that TMB (especially related frustration) appears to aggravate insomnia, which in turn leads to sleep aid use. Similarly, but to a lesser extent, the relationship between ISI and sleep medication use was explained by TMB, in that ISI may lead to increased TMB, which may in turn lead to sleep aid use. TMB and the associated frustration it engenders may perpetuate a negative cycle of insomnia and sleep aid use. Future longitudinal and interventional research is necessary to examine the developmental course of these clinical symptoms and behaviors and to test whether decreasing frustration by limiting TMB reduces the proclivity for pharmacotherapy.

摘要

非处方 (OTC) 和处方助眠药物常被用于治疗慢性失眠,尽管存在风险且长期疗效有限。研究这种对药物治疗偏好的潜在机制可能会发现减少对睡眠辅助药物依赖的策略。本研究旨在确定时间监测行为(TMB;看表)和相关挫折感如何与失眠症状相互作用,从而导致睡眠辅助药物的使用。2003 年 5 月至 2013 年 10 月期间,在一家社区私人睡眠医学中心就诊的患者(N=4886)完成了失眠严重程度指数(ISI)和时间监测行为-10 项(TMB-10),并报告了他们使用睡眠药物的频率(OTC 和处方,分别)。中介分析检查了时钟监视和相关挫折感如何与失眠症状和药物使用相关。TMB 与睡眠药物使用之间的关系通过 ISI 得到了显著解释( < .05),即 TMB(尤其是相关挫折感)似乎会加重失眠,进而导致助眠药物的使用。类似地,但程度较小,ISI 和睡眠药物使用之间的关系也可以通过 TMB 来解释,即 ISI 可能导致 TMB 增加,进而导致助眠药物的使用。TMB 及其引起的相关挫折感可能会使失眠和助眠药物使用的负面循环持续下去。未来的纵向和干预性研究是必要的,以检验这些临床症状和行为的发展过程,并测试通过限制 TMB 减少挫折感是否会降低药物治疗的倾向。

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