Fanning James, Jacob Carolyn, Diaz Isabel, Ibrahim Omer
Chicago Cosmetic Surgery and Dermatology, Chicago, Illinois, USA.
Dermal Clinical Research, Colgate-Palmolive Company, New Jersey, Piscataway, USA.
J Cosmet Dermatol. 2023 Nov;22(11):3033-3041. doi: 10.1111/jocd.15814. Epub 2023 May 25.
Chemical peeling treats facial cutaneous aging and may avoid risks in patients with sensitive skin, darker skin types, limited finances, or concern for side effects of other resurfacing techniques. Tolerability and improvement of photoaging using a combination peel containing 6% trichloroacetic acid and 12% lactic acid for treatment of mild-to-moderate signs of facial photoaging were assessed. This is a prospective, single-center, single-arm, study of 32 female subjects with mild-to-moderate signs of facial aging and Fitzpatrick Skin Types I-V treated with three monthly treatments of a combination peel containing 6% trichloroacetic acid and 12% lactic acid. After 3 treatments, there were statistically significant improvements in clarity, brightness, redness, pigmentation, fine lines, tactile and visual roughness, and overall appearance scores. Subjective improvements in photoaging parameters varied from 53% (fine lines) to 91% (clarity/brightness). Three treatments with a combination peel containing 6% trichloroacetic acid and 12% lactic acid achieved improvements in signs of facial photoaging. This procedure is safe and effective at treating cutaneous aging for all skin types and a viable option for patients who wish to avoid other resurfacing techniques such as laser resurfacing, microneedling among others.
化学剥脱术可治疗面部皮肤老化，对于皮肤敏感、肤色较深、经济条件有限或担心其他皮肤磨削技术副作用的患者而言，或许可避免风险。本研究评估了使用含6%三氯乙酸和12%乳酸的联合剥脱剂治疗轻至中度面部光老化迹象时的耐受性及光老化改善情况。这是一项前瞻性、单中心、单臂研究，纳入了32名面部有轻至中度老化迹象且皮肤类型为Fitzpatrick I - V型的女性受试者，她们接受了为期三个月、每月一次的含6%三氯乙酸和12%乳酸联合剥脱剂治疗。经过3次治疗后，在清晰度、亮度、泛红、色素沉着、细纹、触感和视觉粗糙度以及整体外观评分方面均有统计学意义上的显著改善。光老化参数的主观改善率从53%（细纹）到91%（清晰度/亮度）不等。使用含6%三氯乙酸和12%乳酸的联合剥脱剂进行三次治疗可改善面部光老化迹象。该方法对于所有皮肤类型治疗皮肤老化均安全有效，对于希望避免其他皮肤磨削技术（如激光磨皮、微针治疗等）的患者来说是一种可行的选择。
