Ardura-Garcia Cristina, Kainz Katharina, Mallet Maria Christina, Petrarca Laura, Rodman Berlot Jasna, Slaats Monique, Streibel Carmen, Vijverberg Susanne, Williams Emma E, Goutaki Myrofora, Gray Diane M, Lavizzari Anna, Morty Rory E, Proesmans Marijke, Schramm Dirk, Stahl Mirjam, Zacharasiewicz Angela, Moeller Alexander, Pijnenburg Mariëlle W
Department of Paediatrics, Fribourg Hospital, Fribourg, Switzerland.
Klinik Ottakring, Wilhelminen Hospital, Department of Paediatrics, Teaching Hospital of the University of Vienna, Vienna, Austria.
ERJ Open Res. 2023 May 22;9(3). doi: 10.1183/23120541.00653-2022. eCollection 2023 May.
This review has been prepared by the Early Career Members and Chairs of the European Respiratory Society (ERS) Assembly 7: Paediatrics. We here summarise the highlights of the advances in paediatric respiratory research presented at the ERS International Congress 2022. The eight scientific groups of this Assembly cover a wide range of research areas, including respiratory physiology and sleep, asthma and allergy, cystic fibrosis (CF), respiratory infection and immunology, neonatology and intensive care, respiratory epidemiology, bronchology, and lung and airway developmental biology. Specifically, we report on abstracts presented at the congress on the effect of high altitude on sleep, sleep disorders, the hypoxic challenge test, and measurements of ventilation inhomogeneity. We discuss prevention of preschool wheeze and asthma, and new asthma medications. In children with CF, we describe how to monitor the effect of CF transmembrane conductance regulator modulator therapy. We present respiratory manifestations and chronic lung disease associated with common variable immunodeficiency. Furthermore, we discuss how to monitor respiratory function in neonatal and paediatric intensive care units. In respiratory epidemiology, we present the latest news from population-based and clinical cohort studies. We also focus on innovative and interventional procedures for the paediatric airway, such as cryotherapy. Finally, we stress the importance of better understanding the molecular mechanisms underlying normal and abnormal lung development.
本综述由欧洲呼吸学会（ERS）第7分会：儿科学的青年成员和主席撰写。在此，我们总结了在2022年ERS国际大会上展示的儿科呼吸研究进展的要点。该分会的八个科学小组涵盖了广泛的研究领域，包括呼吸生理学与睡眠、哮喘与过敏、囊性纤维化（CF）、呼吸道感染与免疫学、新生儿学与重症监护、呼吸流行病学、支气管学以及肺与气道发育生物学。具体而言，我们报告了大会上关于高海拔对睡眠的影响、睡眠障碍、低氧激发试验以及通气不均匀性测量的摘要。我们讨论了学龄前喘息和哮喘的预防以及新型哮喘药物。对于患有CF的儿童，我们描述了如何监测CF跨膜电导调节因子调节剂治疗的效果。我们介绍了与常见变异免疫缺陷相关的呼吸道表现和慢性肺病。此外，我们讨论了如何在新生儿和儿科重症监护病房监测呼吸功能。在呼吸流行病学方面，我们展示了基于人群和临床队列研究的最新消息。我们还关注儿科气道的创新和介入性操作，如冷冻疗法。最后，我们强调更好地理解正常和异常肺发育背后分子机制的重要性。
