Ling Bai, Xu Yunyang, Qian Siyuan, Xiang Ze, Xuan Shihai, Wu Jian
Department of Pharmacy, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Front Cell Dev Biol. 2023 May 9;11:1186850. doi: 10.3389/fcell.2023.1186850. eCollection 2023.
Hematopoietic stem cells (HSCs) are important for the hematopoietic system because they can self-renew to increase their number and differentiate into all the blood cells. At a steady state, most of the HSCs remain in quiescence to preserve their capacities and protect themselves from damage and exhaustive stress. However, when there are some emergencies, HSCs are activated to start their self-renewal and differentiation. The mTOR signaling pathway has been shown as an important signaling pathway that can regulate the differentiation, self-renewal, and quiescence of HSCs, and many types of molecules can regulate HSCs' these three potentials by influencing the mTOR signaling pathway. Here we review how mTOR signaling pathway regulates HSCs three potentials, and introduce some molecules that can work as the regulator of HSCs' these potentials through the mTOR signaling. Finally, we outline the clinical significance of studying the regulation of HSCs three potentials through the mTOR signaling pathway and make some predictions.
造血干细胞（HSCs）对造血系统很重要，因为它们可以自我更新以增加数量，并分化为所有血细胞。在稳态下，大多数造血干细胞保持静止状态，以维持其能力并保护自身免受损伤和过度应激。然而，当出现一些紧急情况时，造血干细胞被激活，开始自我更新和分化。mTOR信号通路已被证明是一条重要的信号通路，它可以调节造血干细胞的分化、自我更新和静止状态，许多类型的分子可以通过影响mTOR信号通路来调节造血干细胞的这三种潜能。在这里，我们综述了mTOR信号通路如何调节造血干细胞的三种潜能，并介绍了一些可以通过mTOR信号作为造血干细胞这些潜能调节因子的分子。最后，我们概述了通过mTOR信号通路研究造血干细胞三种潜能调节的临床意义并做出一些预测。
