迈向对基因-性别相互作用模型的更深入理解。
Toward a deeper understanding of gene-by-sex interaction models.
作者信息
Khramtsova Ekaterina A, Winham Stacey J, Davis Lea K, Stranger Barbara E, Wilson Melissa A
机构信息
Population Analytics and Insights, Data Science Analytics & Insights, Janssen R&D, Spring House, PA, USA.
Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.
出版信息
Cell Genom. 2023 May 10;3(5):100324. doi: 10.1016/j.xgen.2023.100324.
Abstract
In this issue of , Zhu et al. propose amplification as the primary mode for gene-by-sex interactions in complex traits. Khramtsova et al. preview their modeling approach and discuss implications for the future work on the genomics of sex differences.
摘要
在本期杂志中，朱等人提出扩增是复杂性状中基因与性别的相互作用的主要模式。赫拉姆佐娃等人预览了他们的建模方法，并讨论了对未来性别差异基因组学研究工作的影响。
相似文献
1
Toward a deeper understanding of gene-by-sex interaction models.迈向对基因-性别相互作用模型的更深入理解。
Cell Genom. 2023 May 10;3(5):100324. doi: 10.1016/j.xgen.2023.100324.
2
Enhancement of Plant Productivity in the Post-Genomics Era.后基因组时代植物生产力的提高
Curr Genomics. 2016 Aug;17(4):295-6. doi: 10.2174/138920291704160607182507.
3
Genomic discoveries unveil mechanistic insights in diabetes.基因组学发现揭示了糖尿病的机制性见解。
Cell Genom. 2022 Dec 14;2(12):100230. doi: 10.1016/j.xgen.2022.100230.
4
Amplification is the primary mode of gene-by-sex interaction in complex human traits.在复杂的人类性状中，基因与性别的相互作用主要模式是基因扩增。
Cell Genom. 2023 Apr 6;3(5):100297. doi: 10.1016/j.xgen.2023.100297. eCollection 2023 May 10.
5
The role of sex in the genomics of human complex traits.性别在人类复杂特征的基因组学中的作用。
Nat Rev Genet. 2019 Mar;20(3):173-190. doi: 10.1038/s41576-018-0083-1.
7
Concerted Genetic Function in Blood Traits.协同遗传功能在血液特征上的表现。
Cell. 2016 Nov 17;167(5):1167-1169. doi: 10.1016/j.cell.2016.10.055.
8
Evolution of sex: Using experimental genomics to select among competing theories.性别的进化：运用实验基因组学在相互竞争的理论中进行选择。
Bioessays. 2016 Aug;38(8):751-7. doi: 10.1002/bies.201600074. Epub 2016 Jun 17.
10
Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits.单体型功能评分可改善人类复杂性状的生物学解释和跨血统多基因预测。
Elife. 2024 Apr 19;12:RP92574. doi: 10.7554/eLife.92574.
本文引用的文献
1
Amplification is the primary mode of gene-by-sex interaction in complex human traits.在复杂的人类性状中，基因与性别的相互作用主要模式是基因扩增。
Cell Genom. 2023 Apr 6;3(5):100297. doi: 10.1016/j.xgen.2023.100297. eCollection 2023 May 10.
2
Quality control and analytic best practices for testing genetic models of sex differences in large populations.大规模人群中性别差异遗传模型检测的质量控制和分析最佳实践。
Cell. 2023 May 11;186(10):2044-2061. doi: 10.1016/j.cell.2023.04.014.
3
Comparison of Methods Utilizing Sex-Specific PRSs Derived From GWAS Summary Statistics.利用全基因组关联研究（GWAS）汇总统计数据得出的性别特异性多基因风险评分（PRSs）的方法比较。
Front Genet. 2022 Jul 8;13:892950. doi: 10.3389/fgene.2022.892950. eCollection 2022.
4
Sex differences in genetic architecture in the UK Biobank.英国生物库中遗传结构的性别差异。
Nat Genet. 2021 Sep;53(9):1283-1289. doi: 10.1038/s41588-021-00912-0. Epub 2021 Sep 7.
5
Genetic analyses identify widespread sex-differential participation bias.遗传分析确定了广泛存在的性别差异参与偏见。
Nat Genet. 2021 May;53(5):663-671. doi: 10.1038/s41588-021-00846-7. Epub 2021 Apr 22.
6
Evaluating human autosomal loci for sexually antagonistic viability selection in two large biobanks.评估两个大型生物库中人类常染色体基因座的性拮抗生存力选择。
Genetics. 2021 Mar 3;217(1):1-10. doi: 10.1093/genetics/iyaa015.
7
The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics.对性拮抗基因的探索：来自局部适应性研究和统计基因组学的实践见解。
Evol Lett. 2020 Aug 31;4(5):398-415. doi: 10.1002/evl3.192. eCollection 2020 Oct.
8
The role of sex in the genomics of human complex traits.性别在人类复杂特征的基因组学中的作用。
Nat Rev Genet. 2019 Mar;20(3):173-190. doi: 10.1038/s41576-018-0083-1.
Zotero 插件