Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 2020 Dec 15;147(12):3313-3327. doi: 10.1002/ijc.33147. Epub 2020 Jul 22.
Malignant renal tumours represent 5% of childhood cancers and include types with likely different aetiology: Wilms tumour (WT), rhabdoid renal tumour, kidney sarcomas and renal carcinomas. WT is the most common renal tumour in children, previously shown to vary internationally and with ethnicity. Using the comprehensive database of the International Incidence of Childhood Cancer study (IICC), we analysed global variations and time trends in incidence of renal tumour types in children (age 0-14 years) and adolescents (age 15-19 years). The results were presented by 14 world regions, and five ethnic groups in the US. We included 15 320 renal tumours in children and 800 in adolescents reported to the 163 contributing registries during 2001-2010. In children, age-standardised incidence rate (ASR) of renal tumours was 8.3 per million (95% confidence interval, CI = 8.1, 8.4); it was the highest in North America and Europe (9-10 per million) and the lowest in most Asian regions (4-5 per million). In the US, Blacks had the highest ASR (10.9 per million, 95% CI = 10.2, 11.6) and Asian and Pacific Islanders the lowest (4.4 per million, 95% CI = 3.6, 5.1). In adolescents, age-specific incidence rate of renal tumours was 1.4 per million (95% CI = 1.3, 1.5). WT accounted for over 90% of all renal tumours in each age from 1 to 7 years and the proportion of renal carcinomas increased gradually with age. From 1996 to 2010, incidence remained mostly stable for WT (average annual percent change, AAPC = 0.1) and increased for renal carcinomas in children (AAPC = 3.7) and adolescents (AAPC = 3.2). Our findings warrant further monitoring.
恶性肾肿瘤占儿童癌症的 5%，包括可能具有不同病因的类型：Wilms 瘤（WT）、横纹肌样肾肿瘤、肾肉瘤和肾癌。WT 是儿童中最常见的肾肿瘤，以前在国际上和不同种族中都有差异。利用国际儿童癌症发病率研究（IICC）的综合数据库，我们分析了全球儿童（0-14 岁）和青少年（15-19 岁）肾肿瘤类型的发病率变化和时间趋势。结果按 14 个世界区域和美国的 5 个种族群体呈现。我们纳入了 2001-2010 年期间 163 个参与登记处报告的 15320 例儿童肾肿瘤和 800 例青少年肾肿瘤。在儿童中，肾肿瘤的年龄标准化发病率（ASR）为每百万 8.3（95%置信区间，CI=8.1，8.4）；北美的发病率最高（每百万 9-10），而大多数亚洲地区的发病率最低（每百万 4-5）。在美国，黑人的 ASR 最高（每百万 10.9，95%CI=10.2，11.6），亚洲和太平洋岛民最低（每百万 4.4，95%CI=3.6，5.1）。在青少年中，肾肿瘤的年龄特异性发病率为每百万 1.4（95%CI=1.3，1.5）。WT 在每个年龄（1-7 岁）占所有肾肿瘤的 90%以上，而肾癌的比例随着年龄的增长逐渐增加。从 1996 年到 2010 年，WT 的发病率基本保持稳定（平均年变化百分比，AAPC=0.1），儿童（AAPC=3.7）和青少年（AAPC=3.2）的肾癌发病率增加。我们的发现需要进一步监测。
