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中枢神经系统弓形虫病,在重症肌无力患者中罕见的表现。

CNS toxoplasmosis, a rare presentation in a patient with Myasthenia Gravis.

作者信息

King Rachel, Sekar Poorani, Patel Henna, Naveed Maryam, Aqtash Sumaia, Adroja Shubham, Jacob Denise, Riaz Talha

机构信息

Department of Internal Medicine, Cleveland Clinic Akron General, Akron, OH, USA.

Division of Infectious Diseases, Western Reserve Hospital, Cuyahoga falls, OH, USA.

出版信息

IDCases. 2023 May 9;32:e01780. doi: 10.1016/j.idcr.2023.e01780. eCollection 2023.

Abstract

We report the case of a 78-year-old man with a past medical history of non-Hodgkin's lymphoma s/p chemotherapy and Myasthenia Gravis on chronic mycophenolate mofetil (MMF), who presented with altered mental status and was found to have ring enhancing brain lesions. A brain biopsy revealed organisms consistent with . Cerebral toxoplasmosis has been rarely reported in patients with hematologic malignancies or in those receiving immunosuppressive agents. There needs to be a high degree of suspicion for in HIV-negative individuals who are on immunosuppressants drugs including MMF.

摘要

我们报告了一例78岁男性病例,其既往有非霍奇金淋巴瘤化疗史,患重症肌无力并长期服用霉酚酸酯(MMF),该患者出现精神状态改变,经检查发现脑部有环形强化病变。脑活检显示有符合……的病原体。脑型弓形虫病在血液系统恶性肿瘤患者或接受免疫抑制剂治疗的患者中鲜有报道。对于正在服用包括MMF在内的免疫抑制药物的HIV阴性个体,需要高度怀疑……

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