Tai Yanghao, Chen Bin, Kong Yingming, Shang Jiwen
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, China.
Department of Urology, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
Front Endocrinol (Lausanne). 2025 May 8;16:1531221. doi: 10.3389/fendo.2025.1531221. eCollection 2025.
A common pathophysiological association between lipid metabolism and sex hormone levels has been revealed in recent research. The atherogenic index of plasma (AIP) is the marker currently used to evaluate metabolism. The purpose of this research was to discover the relationship between the AIP and testosterone deficiency (TD) in a nationwide representative population.
Data from the National Health and Nutrition Examination Survey (NHANES) database from 2011 to 2016 were utilized in this cross-sectional research. The formula, lg [TG (mmol/L)/HDL-C(mmol/L)], was applied to determine the AIP. Total serum testosterone levels were used to define TD. Our researcher utilized smoothed curve fitting and multivariate logistic or linear regression analysis to inspect the relationship between AIP and TD among adult males. The consistency of these results was examined in various population subgroups.
In total, 1,198 individuals (28.6%) were stratified into the TD group. We observed statistically significant differences (P values < 0.05) in the TD population for all variables. After correcting for potential confounders, our researchers discovered a strong positive relationship between the AIP and the probability of developing TD. With each additional unit of the AIP, the incidence of TD increased by 2.81-fold in adult males. Subgroup analyses showed the correlations for the majority of the subgroups remained stable. However, marital status, CKD, smoking, and alcohol consumption may modify this association.
A higher AIP is correlated with a lower level of testosterone in adult males. This correlation may be altered by factors including marriage, chronic kidney disease, alcohol, and smoking consumption.
近期研究揭示了脂质代谢与性激素水平之间常见的病理生理关联。血浆致动脉粥样硬化指数（AIP）是目前用于评估代谢的标志物。本研究的目的是在全国代表性人群中发现AIP与睾酮缺乏（TD）之间的关系。
本横断面研究使用了2011年至2016年国家健康与营养检查调查（NHANES）数据库中的数据。应用公式lg [甘油三酯（mmol/L）/高密度脂蛋白胆固醇（mmol/L）]来确定AIP。血清总睾酮水平用于定义TD。我们的研究人员利用平滑曲线拟合和多变量逻辑或线性回归分析来研究成年男性中AIP与TD之间的关系。在不同人群亚组中检验了这些结果的一致性。
总共1198人（28.6%）被分层到TD组。我们观察到TD人群中所有变量在统计学上有显著差异（P值<0.05）。在校正潜在混杂因素后，我们的研究人员发现AIP与发生TD的概率之间存在强正相关。AIP每增加一个单位，成年男性中TD的发生率增加2.81倍。亚组分析表明，大多数亚组的相关性保持稳定。然而，婚姻状况、慢性肾脏病、吸烟和饮酒可能会改变这种关联。
成年男性中较高的AIP与较低的睾酮水平相关。这种相关性可能会因婚姻、慢性肾脏病、饮酒和吸烟等因素而改变。
