Kherudkar Aditya, Bhattacharjee Angana, Nawkhare Akash, Mukherjee Soumi, Pramanick Sukhendu, Laha Joydev K
Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education & Research (NIPER) S.A.S. Nagar, 160062, Mohali, India.
Chem Rec. 2023 Oct;23(10):e202300063. doi: 10.1002/tcr.202300063. Epub 2023 May 25.
Aldehydes serve as the key functional group in organic synthesis and are valuable intermediates. The various advanced methods of direct formylation reactions have been reviewed in this article. Overcoming the drawbacks of the traditional methods of formylation, newer methods involving homo and heterogenous catalysts, one pot reactions, solvent free techniques are elaborated, which can be performed under mild conditions and using inexpensive resources.
醛类是有机合成中的关键官能团,也是重要的中间体。本文综述了各种直接甲酰化反应的先进方法。克服了传统甲酰化方法的缺点,阐述了涉及均相和非均相催化剂、一锅法反应、无溶剂技术的新方法,这些方法可以在温和条件下使用廉价资源进行。