Service de Médecine Interne, Hôpital Européen, Marseille, France.
Service de Néphrologie, Hôpital de la Conception, Marseille Public University Hospital System, Marseille, France.
Lupus. 2023 Jul;32(8):942-951. doi: 10.1177/09612033231179773. Epub 2023 May 25.
Recent studies have highlighted that systemic lupus erythematosus (SLE) is characterized by different types of symptoms: type 1 symptoms related to inflammation and disease activity and type 2 symptoms such as fatigue, anxiety-depression, and pain. Our aim was to investigate the relation between type 1 and type 2 symptoms, and their impact on health-related quality of life (HRQoL) in SLE.
A literature review was conducted about disease activity/type1 and type 2 symptoms. Articles in English published after 2000 were located on Medline via Pubmed. The articles chosen evaluated at least one type 2 symptom or HRQoL using a validated scale in adult patients.
Overall, 182 articles were analyzed and 115 were retained including 21 randomized, controlled trials and corresponding to 36 831 patients. We found that in SLE, inflammatory activity/type 1 symptoms were mostly uncorrelated with type 2 symptoms and/or HRQoL. Several studies even showing an inverse relationship. No or weak correlation was observed in 85, 3% (92, 6%), 76, 7% (74, 4%) and 37, 5% (73, 1%) of studies (patients) for fatigue, anxiety-depression, and pain, respectively. For HRQoL, no or weak correlation was observed in 77, 5% of studies (88% of patients).
Type 2 symptoms are poorly correlated with inflammatory activity/type 1 symptoms in SLE. Possible explanations and implications for clinical care and therapeutic evaluation are discussed.
最近的研究强调，系统性红斑狼疮（SLE）的特征是不同类型的症状：与炎症和疾病活动相关的 1 型症状和疲劳、焦虑-抑郁和疼痛等 2 型症状。我们的目的是研究 1 型和 2 型症状之间的关系，以及它们对 SLE 患者健康相关生活质量（HRQoL）的影响。
对疾病活动/1 型和 2 型症状进行了文献回顾。通过 Pubmed 在 Medline 上检索了 2000 年后发表的英文文章。选择的文章至少使用成人患者的验证量表评估了 1 种 2 型症状或 HRQoL。
共分析了 182 篇文章，保留了 115 篇，包括 21 项随机对照试验和 36831 例患者。我们发现，在 SLE 中，炎症活动/1 型症状与 2 型症状和/或 HRQoL 大多没有相关性。一些研究甚至显示出相反的关系。在 85%（92，6%）、76.7%（74，4%）和 37.5%（73，1%）的研究（患者）中，疲劳、焦虑-抑郁和疼痛分别观察到无或弱相关性。在 77%的研究（88%的患者）中，HRQoL 观察到无或弱相关性。
SLE 中 2 型症状与炎症活动/1 型症状相关性差。讨论了可能的解释及其对临床护理和治疗评估的影响。
