Department of Infectious Diseases AIG Hospitals, Gachibowli, Hyderabad 500032, India.
Department of Nephrology and Renal Transplant, AIG Hospitals, Tower A, 1st floor, Gachibowli, Hyderabad 500032, India.
J Mycol Med. 2023 Aug;33(3):101406. doi: 10.1016/j.mycmed.2023.101406. Epub 2023 May 13.
Cryptococcal meningitis is a life-threatening infection commonly seen in patients with advanced HIV infection and solid organ transplant recipients. We report a case of cryptococcal meningitis with immune reconstitution syndrome (IRIS) who presented to us with a headache and complete loss of vision in the left eye. He was managed with antifungals and a short course of steroids, and he regained vision completely. In the hospital, he developed complications including tacrolimus toxicity, fluconazole-induced QT prolongation, and flucytosine-induced thrombocytopenia. Our case demonstrates the importance of a multidisciplinary approach in the management of complex cases like cryptococcal meningitis in solid organ transplant recipients.
隐球菌性脑膜炎是一种危及生命的感染，常见于晚期 HIV 感染和实体器官移植受者。我们报告了一例免疫重建综合征（IRIS）合并隐球菌性脑膜炎的病例，该患者以头痛和左眼完全失明就诊。他接受了抗真菌药物和短期类固醇治疗，视力完全恢复。住院期间，他出现了多种并发症，包括他克莫司毒性、氟康唑引起的 QT 间期延长和氟胞嘧啶引起的血小板减少症。我们的病例表明，在管理实体器官移植受者的隐球菌性脑膜炎等复杂病例时，多学科方法的重要性。
