Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600# Tianhe Road, Guangzhou, Guangdong, 510630, China.
Future Microbiol. 2023 Jun;18:541-545. doi: 10.2217/fmb-2022-0268. Epub 2023 Jun 14.
A 49-year-old woman with a rare autoimmune hematological disease, Evans syndrome, was admitted to the authors' hospital with immune reconstitution inflammatory syndrome-like reconstitution syndrome after effective antifungal therapy for cryptococcal meningitis. She initially improved after receiving corticosteroid treatment; after prednisone was tapered, her clinical presentation and brain imaging deteriorated but finally improved with the addition of thalidomide. Immune reconstitution inflammatory syndrome-like reconstitution syndrome is a rare complication in cryptococcal meningitis patients receiving immunosuppressive therapy. Thalidomide can be given in addition to corticosteroid therapy to effectively control the paradoxical inflammatory response and improve clinical outcomes.
一位 49 岁的女性患有罕见的自身免疫性血液疾病， Evans 综合征，在隐球菌性脑膜炎接受有效的抗真菌治疗后，因免疫重建炎症综合征样重建综合征而入住作者医院。她在接受皮质类固醇治疗后最初有所改善；泼尼松减量后，她的临床表现和脑部影像学恶化，但最终在加入沙利度胺后有所改善。免疫重建炎症综合征样重建综合征是接受免疫抑制治疗的隐球菌性脑膜炎患者的一种罕见并发症。可以在皮质类固醇治疗的基础上给予沙利度胺，以有效控制矛盾性炎症反应并改善临床结局。
