Frischkorn Marie, Fortelny Michael, Ciurkiewicz Malgorzata, Krüger Johannes, Jahn-Falk Doris
Praxis und Klinik für Rinder, Dr. Doris Jahn-Falk, Dr. Konrad Bierhorst, Hofbieber.
Institut für Pathologie der Stiftung Tierärztliche Hochschule Hannover.
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2023 Apr;51(2):109-115. doi: 10.1055/a-2030-6701. Epub 2023 May 25.
The presented report describes a case of sporadic bovine leukosis and its disease progression in an 8-week old, male cross-breed calf (Red Holstein Fleckvieh). The calf was initially presented due to suspect pulmonary infection. However, generalized enlargement of the subcutaneous lymph nodes was noticed, which is untypical for this disease. Based on the hematologic findings of highly increased numbers of lymphoblasts in peripheral blood as well as the sonographic examination of the lymph nodes, sporadic bovine leukosis was suspected. The calf died suddenly, three weeks after initial presentation. Pathohistological examination revealed a high-degree enlargement of all lymph nodes as well as an infiltration of nearly all organs and tissues with a monomorphic round cell population. These cells were also detected in bone marrow cytology. Immunhistochemical examination was performed and the cells reacted positive for the B-cell markers Pax 5 and CD20. Virologic examination for enzootic bovine leukosis was negative. In conjunction with the diagnosis of multicentric B-cell lymphoma, the test results indicated a juvenile form of sporadic bovine lymphoma.
本报告描述了一例散发性牛白血病及其在一头8周龄雄性杂交犊牛（红荷斯坦弗莱维赫牛）中的疾病进展情况。该犊牛最初因疑似肺部感染就诊。然而，发现皮下淋巴结普遍肿大，这在该疾病中并不典型。基于外周血中淋巴母细胞数量大幅增加的血液学检查结果以及淋巴结的超声检查，怀疑为散发性牛白血病。该犊牛在初次就诊三周后突然死亡。病理组织学检查显示所有淋巴结高度肿大，几乎所有器官和组织均有单形性圆形细胞浸润。这些细胞在骨髓细胞学检查中也被检测到。进行了免疫组织化学检查，细胞对B细胞标志物Pax 5和CD20呈阳性反应。地方流行性牛白血病的病毒学检查结果为阴性。结合多中心B细胞淋巴瘤的诊断，检测结果表明为散发性牛淋巴瘤的幼年型。
