Laboratory of Farm Animal Medicine, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
Beef Cattle Research Center, Ibaraki Prefecture, Ibaraki, Japan.
J Vet Med Sci. 2024 Sep 10;86(9):969-973. doi: 10.1292/jvms.24-0152. Epub 2024 Jul 26.
A 5-year-old Japanese Black cow presented with astasia. Bovine leukemia virus (BLV) was detected in the peripheral blood with lower proviral load (PVL). No enlargement of surface lymph nodes or lymphocytosis was observed. Necropsy revealed no enlarged lymph nodes in the thoracic, abdominal, or pelvic cavity. Spinal epidural and peri-medullary adipose tissue was increased in the spinal canal of lumbar to sacral vertebrae, Histopathological examination revealed tumor invasion of the epidural adipose tissue, and a diagnosis of B-cell lymphoma was made. The PVL in tumor tissue was higher, and monoclonal integration of BLV was confirmed. It was a rare case of bovine enzootic leukosis that formed a solitary mass around the spinal cord which might cause hindlimb paresis.
一头 5 岁的日本黑牛出现步态失调。在外周血中检测到牛白血病病毒 (BLV)，病毒载量较低。未观察到表面淋巴结肿大或淋巴细胞增多。尸检未发现胸、腹或盆腔内淋巴结肿大。腰椎至荐椎椎管内的硬脊膜外和髓周脂肪组织增多。组织病理学检查显示硬脊膜外脂肪组织有肿瘤浸润，诊断为 B 细胞淋巴瘤。肿瘤组织中的病毒载量更高，并且证实了 BLV 的单克隆整合。这是一例罕见的牛地方性白血病病例，在脊髓周围形成单一肿块，可能导致后肢瘫痪。
