Wada L, King J C
J Nutr. 1986 Jun;116(6):1045-53. doi: 10.1093/jn/116.6.1045.
Basal metabolic rate (BMR), thyroid hormones and protein utilization were measured in six young men participating in a 75-d metabolic study of low zinc intakes. During metabolic period (MP) 1 (12 d) and MP 3 (9 d) the subjects received 16.5 mg Zn/d. During MP 2 (54 d) they received 5.5 mg Zn/d. Nitrogen intake averaged 12.6 g/d. Mean BMR significantly decreased from 1.00 +/- 0.06 to 0.91 +/- 0.05 kcal/(kg X h) (mean +/- SD) with the low zinc diet and tended to increase during period 3. Serum thyroid-stimulating hormone, thyroxine (T4) and free T4 tended to decrease during the low zinc period and to increase when the adequate zinc diet was fed; only the decrease in free T4 was significant at P less than 0.05, however. Among the measures of protein status, urinary urea excretion, serum prealbumin, albumin and retinol-binding protein levels all decreased significantly during the low zinc period. The results suggest that low zinc intakes may be associated with decreases in BMR. In addition, decreases in thyroid hormone levels and alterations in protein utilization may occur.
对六名参与低锌摄入量75天代谢研究的年轻男性测量了基础代谢率（BMR）、甲状腺激素和蛋白质利用率。在代谢期（MP）1（12天）和MP 3（9天），受试者每天摄入16.5毫克锌。在MP 2（54天）期间，他们每天摄入5.5毫克锌。氮摄入量平均为每天12.6克。低锌饮食时，平均基础代谢率从1.00±0.06显著降至0.91±0.05千卡/（千克×小时）（平均值±标准差），在第3阶段有上升趋势。在低锌期，血清促甲状腺激素、甲状腺素（T4）和游离T4趋于下降，而给予充足锌饮食时则趋于上升；然而，只有游离T4的下降在P<0.05时具有显著性。在蛋白质状态的各项指标中，低锌期尿尿素排泄、血清前白蛋白、白蛋白和视黄醇结合蛋白水平均显著下降。结果表明，低锌摄入量可能与基础代谢率降低有关。此外，可能会出现甲状腺激素水平下降和蛋白质利用改变的情况。
