Department of Health Sciences, University of Florence, 50139, Florence, Italy.
Department of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy.
Future Oncol. 2023 Apr;19(13):937-946. doi: 10.2217/fon-2023-0137. Epub 2023 May 26.
Pancreatic cancer (PC) is one of the most lethal malignancies worldwide. This study evaluated the prognostic role of serum alanine phosphatase (ALP) and gamma-glutamyl-transferase (GGT) in metastatic PC patients. 153 patients with metastatic PC receiving first-line treatment with nab-paclitaxel/gemcitabine were retrospectively enrolled in a multicenter study and stratified according to ALP (≤ or >260 U/l) and GGT (≤ or >45.5 U/l) levels. Improved overall survival was recorded in patients with GGT levels ≤45.5 U/l (p < 0.05). In patients with liver metastasis, overall survival was significantly lower in patients with high ALP (p = 0.01) and GGT (p = 0.02). High levels of ALP and GGT were related to a poor prognosis in PC patients with liver metastasis receiving nab-paclitaxel/gemcitabine.
胰腺癌（PC）是全球最致命的恶性肿瘤之一。本研究评估了血清丙氨酸磷酸酶（ALP）和γ-谷氨酰转移酶（GGT）在转移性 PC 患者中的预后作用。153 名接受纳武利尤单抗/吉西他滨一线治疗的转移性 PC 患者被纳入一项多中心回顾性研究，并根据 ALP（≤或>260 U/l）和 GGT（≤或>45.5 U/l）水平进行分层。GGT 水平≤45.5 U/l 的患者的总生存期得到改善（p<0.05）。在有肝转移的患者中，ALP 和 GGT 水平较高的患者总生存期明显较低（p=0.01 和 p=0.02）。在接受纳武利尤单抗/吉西他滨治疗的有肝转移的 PC 患者中，ALP 和 GGT 水平较高与预后不良相关。
