Takematsu Eri, Murphy Matthew, Hou Sophia, Steininger Holly, Alam Alina, Ambrosi Thomas H, Chan Charles K F
Department of Surgery, Stanford Medicine, Stanford, CA 94305, USA.
Blond McIndoe Laboratories, School of Biological Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PR, UK.
Gels. 2023 May 3;9(5):377. doi: 10.3390/gels9050377.
Bone- and cartilage-related diseases, such as osteoporosis and osteoarthritis, affect millions of people worldwide, impairing their quality of life and increasing mortality. Osteoporosis significantly increases the bone fracture risk of the spine, hip, and wrist. For successful fracture treatment and to facilitate proper healing in the most complicated cases, one of the most promising methods is to deliver a therapeutic protein to accelerate bone regeneration. Similarly, in the setting of osteoarthritis, where degraded cartilage does not regenerate, therapeutic proteins hold great promise to promote new cartilage formation. For both osteoporosis and osteoarthritis treatments, targeted delivery of therapeutic growth factors, with the aid of hydrogels, to bone and cartilage is a key to advance the field of regenerative medicine. In this review article, we propose five important aspects of therapeutic growth factor delivery for bone and cartilage regeneration: (1) protection of protein growth factors from physical and enzymatic degradation, (2) targeted growth factor delivery, (3) controlling GF release kinetics, (4) long-term stability of regenerated tissues, and (5) osteoimmunomodulatory effects of therapeutic growth factors and carriers/scaffolds.
骨和软骨相关疾病，如骨质疏松症和骨关节炎，影响着全球数百万人，损害他们的生活质量并增加死亡率。骨质疏松症显著增加脊柱、髋部和腕部的骨折风险。为了成功治疗骨折并在最复杂的病例中促进适当愈合，最有前景的方法之一是递送治疗性蛋白质以加速骨再生。同样，在骨关节炎的情况下，退化的软骨不会再生，治疗性蛋白质有望促进新的软骨形成。对于骨质疏松症和骨关节炎的治疗，借助水凝胶将治疗性生长因子靶向递送至骨和软骨是推动再生医学领域发展的关键。在这篇综述文章中，我们提出了治疗性生长因子递送用于骨和软骨再生的五个重要方面：（1）保护蛋白质生长因子免受物理和酶促降解，（2）靶向生长因子递送，（3）控制生长因子释放动力学，（4）再生组织的长期稳定性，以及（5）治疗性生长因子和载体/支架的骨免疫调节作用。
