Al-Oanzi Ziad H, Alenazy Fawaz O, Alhassan Hassan H, Alruwaili Yasir, Alessa Abdulaziz I, Alfarm Nouf B, Alanazi Maha O, Alghofaili Sarah I
Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.
Department of Pharmacy, Prince Sultan Cardiac Center, Riyadh 11159, Saudi Arabia.
J Cardiovasc Dev Dis. 2023 May 11;10(5):209. doi: 10.3390/jcdd10050209.
Among the most common problems facing public health today is a lack of vitamin D, which plays a role in the physiological processes of chronic illness conditions. Vitamin D deficiency in metabolic disorders has primary effects on osteoporosis, obesity, hypertension, diabetes, and cardiovascular disease (CVD). Vitamin D acts as a "co-hormone" in the various tissues of the body, and it has been found that vitamin D receptors (VDR) are present on all cell types, suggesting that vitamin D has a wide range of effects on most cells. Recently, there has been a surge in interest in assessing its roles. Vitamin D insufficiency increases the risk of diabetes because it lowers insulin sensitivity, and also raises the risk of obesity and CVD because of its effect on the body's lipid profile, particularly in terms of the prevalence of dangerously high levels of low-density lipoproteins (LDL). Furthermore, vitamin D insufficiency is often related to CVD and connected risk factors, highlighting the need to know vitamin D's functions in relation to metabolic syndrome and related processes. Through looking at previous studies, this paper explains why vitamin D is important, how deficiency is related to risk factors for metabolic syndrome through different mechanisms, and how deficiency affects CVD.
当今公共卫生面临的最常见问题之一是缺乏维生素D,它在慢性病的生理过程中发挥作用。代谢紊乱中的维生素D缺乏对骨质疏松症、肥胖症、高血压、糖尿病和心血管疾病(CVD)有主要影响。维生素D在人体的各种组织中充当“辅助激素”,并且已经发现所有细胞类型上都存在维生素D受体(VDR),这表明维生素D对大多数细胞有广泛影响。最近,人们对评估其作用的兴趣激增。维生素D不足会增加患糖尿病的风险,因为它会降低胰岛素敏感性,还会增加肥胖症和心血管疾病的风险,因为它会影响人体的血脂状况,特别是就危险的高水平低密度脂蛋白(LDL)的患病率而言。此外,维生素D不足通常与心血管疾病及相关风险因素有关,这凸显了了解维生素D与代谢综合征及相关过程有关的功能的必要性。通过回顾以往的研究,本文解释了为什么维生素D很重要,缺乏维生素D如何通过不同机制与代谢综合征的风险因素相关,以及缺乏维生素D如何影响心血管疾病。