Suzuki T, Chiang H J, Yanaura S, Yoshida T, Kuroiwa Y
J Pharmacobiodyn. 1986 Mar;9(3):234-8. doi: 10.1248/bpb1978.9.234.
Interactions between methamphetamine and quinine were studied using two different tests. The duration and intensity of methamphetamine-induced stereotyped behavior was enhanced by pretreatment of rats with quinine. Pretreatment of rats with SKF-525A and CCl4 also resulted in the enhancement of methamphetamine-induced stereotyped behavior. Pretreatment with phenobarbital shortened the stereotypy evoked by methamphetamine. Furthermore, urinary excretion patterns of methamphetamine and its metabolites were determined following the administration of the drug to rats which had been pretreated with certain drugs. Quinine, SKF-525A and CCl4 inhibited the urinary excretion of p-hydroxylated metabolites and increased the excretion of the unchanged methamphetamine and amphetamine. These results strongly suggest that the enhancement of methamphetamine-induced stereotyped behavior in the rats pretreated with quinine, SKF-525A and CCl4 could be ascribed to the inhibition of the p-hydroxylation reaction of methamphetamine and thus may lead to the increased concentration and pharmacological effect of the drug.
使用两种不同的试验研究了甲基苯丙胺与奎宁之间的相互作用。用奎宁预处理大鼠可增强甲基苯丙胺诱导的刻板行为的持续时间和强度。用SKF - 525A和四氯化碳预处理大鼠也会导致甲基苯丙胺诱导的刻板行为增强。用苯巴比妥预处理可缩短甲基苯丙胺诱发的刻板行为。此外，在给经某些药物预处理的大鼠给药后，测定了甲基苯丙胺及其代谢物的尿排泄模式。奎宁、SKF - 525A和四氯化碳抑制了对羟基化代谢物的尿排泄，并增加了未变化的甲基苯丙胺和苯丙胺的排泄。这些结果有力地表明，用奎宁、SKF - 525A和四氯化碳预处理的大鼠中甲基苯丙胺诱导的刻板行为增强可能归因于甲基苯丙胺对羟基化反应的抑制，因此可能导致药物浓度和药理作用增加。
