L-组氨酸预处理对大鼠甲基苯丙胺诱导的刻板行为的影响。
Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats.
作者信息
Muley M P, Balsara J J, Chandorkar A G
出版信息
Indian J Physiol Pharmacol. 1979 Oct-Dec;23(4):291-6.
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.
研究发现，用组胺的L-组氨酸前体进行预处理可延迟甲基苯丙胺诱导的刻板行为的发作，缩短其持续时间并降低其强度，而H1受体阻滞剂氯环利嗪不仅会增强甲基苯丙胺诱导的刻板行为，还会阻断L-组氨酸对甲基苯丙胺刻板行为的抑制作用。我们的结果表明，中枢组胺能系统通过对纹状体多巴胺能系统施加调节性影响，可能会影响锥体外系运动系统的功能。
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