Suzuki T, Fan Chiang H J, Yanaura S, Yoshida T, Kuroiwa Y
Jpn J Pharmacol. 1984 Jul;35(3):273-7. doi: 10.1254/jjp.35.273.
The behavioral effect and acute toxicity of methamphetamine were tested alone and in combination with quinine in rats. Quinine prolonged and increased the effect of methamphetamine. The enhancement of methamphetamine-induced stereotyped behavior was very marked when quinine was given prior to or simultaneously with methamphetamine. However, the time for onset of methamphetamine-induced stereotyped behavior was not affected by quinine. The mortality of methamphetamine was also potentiated markedly by quinine. The enhancement of the behavioral effect and the toxicity of methamphetamine may be due to inhibition of the metabolism of methamphetamine by quinine.
在大鼠中单独测试了甲基苯丙胺的行为效应和急性毒性，并将其与奎宁联合测试。奎宁延长并增强了甲基苯丙胺的效应。当在给予甲基苯丙胺之前或同时给予奎宁时，甲基苯丙胺诱导的刻板行为增强非常明显。然而，奎宁并不影响甲基苯丙胺诱导的刻板行为的起效时间。奎宁也显著增强了甲基苯丙胺的致死率。甲基苯丙胺行为效应和毒性的增强可能是由于奎宁抑制了甲基苯丙胺的代谢。
