Ciapponi Camilla, Li Yuhe, Osorio Becerra Dianela A, Rodarie Dimitri, Casellato Claudia, Mapelli Lisa, D'Angelo Egidio
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Centro Ricerche Enrico Fermi, Rome, Italy.
Front Syst Neurosci. 2023 May 10;17:1185752. doi: 10.3389/fnsys.2023.1185752. eCollection 2023.
The cerebellum operates exploiting a complex modular organization and a unified computational algorithm adapted to different behavioral contexts. Recent observations suggest that the cerebellum is involved not just in motor but also in emotional and cognitive processing. It is therefore critical to identify the specific regional connectivity and microcircuit properties of the emotional cerebellum. Recent studies are highlighting the differential regional localization of genes, molecules, and synaptic mechanisms and microcircuit wiring. However, the impact of these regional differences is not fully understood and will require experimental investigation and computational modeling. This review focuses on the cellular and circuit underpinnings of the cerebellar role in emotion. And since emotion involves an integration of cognitive, somatomotor, and autonomic activity, we elaborate on the tradeoff between segregation and distribution of these three main functions in the cerebellum.
小脑通过利用复杂的模块化组织和适用于不同行为情境的统一计算算法来运作。最近的观察结果表明，小脑不仅参与运动，还参与情感和认知处理。因此，确定情感小脑的特定区域连接性和微电路特性至关重要。最近的研究突出了基因、分子、突触机制和微电路布线的差异区域定位。然而，这些区域差异的影响尚未完全了解，需要进行实验研究和计算建模。本综述重点关注小脑在情感中作用的细胞和电路基础。而且由于情感涉及认知、躯体运动和自主活动的整合，我们阐述了小脑这三种主要功能在分离和分布之间的权衡。
