Manley M, Sweeney J
J Psychosom Res. 1986;30(2):153-61. doi: 10.1016/0022-3999(86)90045-0.
Research in hemodialysis adaptation has been facilitated by the use of reliable outcome measures such as BUN, K, and interdialysis weight gain. Their use, however, has at times been impressionistic, without reference to the actual range and distribution of those markers in a large population of dialysis patients over a long period of time. This study is a retrospective review to determine that range and distribution at one center. We found the interdialysis weight gains for most patients to be much higher than the levels used in the literature as cut-off points in determining 'non-compliance'. High levels on non-compliance in previous reports may be inflated. Significant correlations among the three biological markers and between each marker and staff assessment of compliance validate the use of inter-dialysis weight gain. Suggestions are made for interpreting such data in the future.
血液透析适应性的研究因使用可靠的预后指标（如尿素氮、钾和透析间期体重增加）而得到推动。然而，这些指标的使用有时只是凭印象，并未参考大量透析患者在很长一段时间内这些指标的实际范围和分布情况。本研究是一项回顾性分析，旨在确定某一中心的这些指标范围和分布情况。我们发现，大多数患者的透析间期体重增加远高于文献中作为判定“不依从”的截断点所使用的水平。先前报告中较高的不依从水平可能存在夸大。这三种生物学指标之间以及每个指标与工作人员对依从性的评估之间存在显著相关性，证实了透析间期体重增加指标的实用性。文中还针对未来如何解读此类数据提出了建议。
