Zhang Zhenmei, Fan Lejia, Yuan Liu, Li Zongchang, Ouyang Lijun, Ma Xiaoqian, Yang Zihao, Lv Jingyan, Chen Shuting, Chen Xiaogang, He Ying
National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hunan Key Laboratory of Psychiatry and Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, Hunan Medical Center for Mental Health, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Front Mol Neurosci. 2023 May 10;16:1177524. doi: 10.3389/fnmol.2023.1177524. eCollection 2023.
Schizophrenia is a neurodevelopmental disorder, characterized by impairment in reasoning, affectivity, and social relationships. Previous studies have shown delayed motor development and Brain-Derived Neurotrophic Factor (BDNF) level change in individuals with schizophrenia. We researched the month of walking alone (MWA) and BDNF level between drug-naive first-episode schizophrenia patients (FEP) and healthy control (HC), as well as how they behave in neurocognitive function and severity of symptoms. Predictors of schizophrenia were further explored too.
We researched the MWA and BDNF levels between FEP and HCs in the Second Xiangya Hospital of Central South University from August 2017 to January 2020, as well as how they behave in neurocognitive function and the severity of symptoms. A binary logistic regression analysis was used to examine the risk factors affecting the onset and treatment outcome of schizophrenia.
We find that FEP showed a walking delay and lower BDNF levels compared to HCs, which were associated with cognitive impairment and severity of symptoms. According to the difference and correlation analysis results, and combined with the appropriate application conditions for binary logistic regression, Wechsler Intelligence Scale Picture completion, Hopkins Verbal Learning Test-Revised, and Trail Making Test: part A were added to the binary logistic regression analysis to distinguish FEP and HCs.
Our study has shown delayed motor development and changes in BDNF levels in schizophrenia, extending insight into the early identification of patients with schizophrenia versus healthy populations.
精神分裂症是一种神经发育障碍，其特征在于推理、情感和社会关系方面的损害。先前的研究表明，精神分裂症患者存在运动发育延迟和脑源性神经营养因子（BDNF）水平变化。我们研究了初发未用药的精神分裂症患者（FEP）和健康对照（HC）之间的独自行走月龄（MWA）和BDNF水平，以及它们在神经认知功能和症状严重程度方面的表现。还进一步探讨了精神分裂症的预测因素。
我们于2017年8月至2020年1月在中南大学湘雅二医院研究了FEP和HC之间的MWA和BDNF水平，以及它们在神经认知功能和症状严重程度方面的表现。采用二元逻辑回归分析来检验影响精神分裂症发病和治疗结果的危险因素。
我们发现，与HC相比，FEP表现出行走延迟和较低的BDNF水平，这与认知障碍和症状严重程度相关。根据差异和相关性分析结果，并结合二元逻辑回归的适用条件，将韦氏智力量表图片填充、修订版霍普金斯言语学习测验和连线测验A部分纳入二元逻辑回归分析以区分FEP和HC。
我们的研究表明精神分裂症存在运动发育延迟和BDNF水平变化，这为精神分裂症患者与健康人群的早期鉴别提供了更多见解。
