Vurro V, Shani K, Ardoña H A M, Zimmerman J F, Sesti V, Lee K Y, Jin Q, Bertarelli C, Parker K K, Lanzani G
Center for Nanoscience and Technology, Istituto Italiano di Teconologia, Milano, 20133 Italy.
Disease Biophysics Group, John A. Paulson School of Engineering and Applied Science, Harvard University, Boston, Massachusetts 02134, USA.
APL Bioeng. 2023 May 23;7(2):026108. doi: 10.1063/5.0143409. eCollection 2023 Jun.
Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation of an cardiac microphysiological model mediated by an amphiphilic azobenzene compound that preferentially dwells in the cell membrane. Exploiting this optical based stimulation technology could be a disruptive approach for highly resolved cardiac tissue stimulation.
光被认为是一种用于刺激可兴奋细胞的精确且非侵入性的工具。在此，我们报告一种基于有机分子光转换器的非遗传方法，该方法可实现无布线和无电极的组织调节。作为概念验证，我们展示了由一种优先驻留在细胞膜中的两亲性偶氮苯化合物介导的心脏微生理模型的光刺激。利用这种基于光学的刺激技术可能是一种用于高分辨率心脏组织刺激的颠覆性方法。
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