Johnston C A, Russell A S, Kovithavongs T, Dasgupta M
J Rheumatol. 1986 Apr;13(2):294-6.
We examined the effects of low dose parenteral methotrexate (MTX) on immunologic and inflammatory responses of potential importance in the pathogenesis of rheumatoid arthritis. Only 2 significant changes were noted: the number of esterase positive cells in the peripheral blood decreased, and the uptake of tritiated thymidine by incubated peripheral blood mononuclear cells fell markedly. These changes were present 48 h after an injection of MTX, before decreased disease activity became clinically apparent. We therefore conclude that they were direct effects of the drug itself.
我们研究了低剂量胃肠外甲氨蝶呤（MTX）对类风湿关节炎发病机制中具有潜在重要性的免疫和炎症反应的影响。仅观察到两个显著变化：外周血中酯酶阳性细胞数量减少，且孵育的外周血单个核细胞对氚标记胸腺嘧啶核苷的摄取显著下降。这些变化在注射MTX后48小时出现，此时疾病活动度降低在临床上尚未明显显现。因此，我们得出结论，它们是药物本身的直接作用。
