Chen Ying, Wang Fei, Rao Weidong, Shen Shusu, Sheng Daopeng, Wang Shun-Yi
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
J Org Chem. 2023 Jul 7;88(13):7953-7961. doi: 10.1021/acs.joc.2c02968. Epub 2023 May 26.
In this work, an efficient method for the copper-catalyzed ring-opening hydrolysis of silacyclobutanes to silanols was developed. This strategy has the advantages of friendly reaction conditions, simple operation, and good functional group compatibility. No additional additives are required in the reaction, and the S-S bond can also be introduced into the organosilanol compounds in one step. Furthermore, the success at the gram scale demonstrates the great potential of the developed protocol for practical industrial applications.
在这项工作中，开发了一种铜催化硅环丁烷开环水解制备硅醇的有效方法。该策略具有反应条件友好、操作简单、官能团兼容性好等优点。反应中无需额外添加物，并且可以一步将S-S键引入有机硅醇化合物中。此外，克级规模的成功证明了所开发方法在实际工业应用中的巨大潜力。
