评估 III 期和 IV 期子宫内膜异位症的新型生物标志物。

Evaluation of new biomarkers in stage III and IV endometriosis.

机构信息

Department of Obstetrics and Gynecology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey.

Department of Medical Biochemistry, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

出版信息

Gynecol Endocrinol. 2023 Dec;39(1):2217290. doi: 10.1080/09513590.2023.2217290.

DOI:10.1080/09513590.2023.2217290

PMID:37236244

Abstract

OBJECTIVE

To investigate the efficacy of new endometriosis biomarkers in diagnosis and treatment.

METHODS

Thirty women with Stage III-IV endometriosis who were given an indication for surgery and 49 control patients were compared. Preoperative and postoperative serum levels of Annexin A5 (ANXA5), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), soluble vascular cell adhesion molecule-1 (sVCAM-1), vascular endothelial growth factors (VEGF) and Ca-125 measurements were compared.

RESULTS

AUCs of ANXA5, sICAM-1, IL-6, TNF-α, VCAM-1, VEGF biomarkers were not found to be significant in diagnosing endometriosis when evaluated alone ( > 0.05). Only the AUC of the Ca-125 biomarker values were found to be significant with 73% sensitivity and 98% specificity ( < 0.001). However, when Ca-125 and ANXA5 were evaluated together, it was concluded that the diagnosis of endometriosis could be made with 73% sensitivity and 100% specificity.

CONCLUSION

When Ca-125 and ANXA5 are evaluated together, it seems to be more valuable than Ca-125 alone in diagnosing endometriosis.

摘要

目的

研究新型子宫内膜异位症生物标志物在诊断和治疗中的疗效。

方法

将 30 名 III-IV 期子宫内膜异位症患者（手术适应证）和 49 名对照患者进行比较。比较术前和术后血清 Annexin A5（ANXA5）、可溶性细胞间黏附分子-1（sICAM-1）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、可溶性血管细胞黏附分子-1（sVCAM-1）、血管内皮生长因子（VEGF）和 CA-125 的水平。

结果

当单独评估时，ANXA5、sICAM-1、IL-6、TNF-α、VCAM-1、VEGF 生物标志物的 AUC 均未发现对子宫内膜异位症的诊断具有显著意义（>0.05）。只有 CA-125 标志物值的 AUC 具有显著意义，其敏感性为 73%，特异性为 98%（<0.001）。然而，当同时评估 CA-125 和 ANXA5 时，得出结论，子宫内膜异位症的诊断可以达到 73%的敏感性和 100%的特异性。