Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Evanston, IL, United States.
Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Evanston, IL, United States.
Vaccine. 2023 Jun 19;41(27):4002-4008. doi: 10.1016/j.vaccine.2023.05.043. Epub 2023 May 24.
INTRODUCTION: The 2022 global outbreak of Monkeypox virus (Mpox), which has primarily spread through the sexual networks of sexual and gender minority (SGM) individuals, has introduced new public health challenges. While an efficacious Mpox vaccine is in active circulation, few Mpox vaccine studies have examined its uptake among SGM groups. The aims of this study were to investigate (a) the prevalence of Mpox vaccine uptake among SGM and (b) the contextual, Mpox-disease specific, and Mpox-vaccine specific factors associated with Mpox vaccine among SGM. METHODS: We conducted a cross-sectional survey in Illinois, USA in September 2022; 320 young SGM completed self-administered questionnaires. Multinomial logistic regression was used to assess the contextual, Mpox-disease specific, and Mpox-vaccine specific factors associated with Mpox vaccine uptake. Adjusted Odds Ratios (aORs) and 95 % Confidence Intervals (CI) are reported. RESULTS: Approximately 50 % of the SGM participants included in this study had received at least their first dose of the Mpox vaccine. Multinomial regression analysis showed that individuals who had recently experienced food insecurity, had higher degrees of fear of social rejection due to Mpox acquisition, and were more Mpox-vaccine hesitant were more likely to be unvaccinated. Conversely, knowing people who have contracted Mpox, having higher formal educational attainment, having higher degrees of Mpox-related internalized heterosexism, and being more concerned about one's safety regarding Mpox morbidity were more likely to be double-dosers. CONCLUSION: Approximately 50 % of the SGMs included in this study received at least their first dose of the Mpox vaccine; however, only one-quarter of participants completed the recommended 2-dose Mpox regimen. Our findings indicate that socioeconomic stability, fear of social rejection due to disease acquisition, and Mpox-specific vaccine hesitancy may be important structural targets to consider when developing vaccine-uptake prevention and intervention strategies tailored to the needs of sexual and gender minorities.
介绍：2022 年，猴痘病毒（Mpox）在全球范围内爆发，主要通过性少数群体（SGM）个体的性网络传播，这给公共卫生带来了新的挑战。虽然一种有效的 Mpox 疫苗正在积极推广，但很少有 Mpox 疫苗研究调查其在 SGM 群体中的接种情况。本研究旨在调查：（a）SGM 群体中 Mpox 疫苗接种的流行率；（b）与 SGM 群体中 Mpox 疫苗接种相关的背景、Mpox 疾病特异性和 Mpox 疫苗特异性因素。 方法：我们于 2022 年 9 月在美国伊利诺伊州进行了一项横断面调查；320 名年轻的 SGM 参与者完成了自我管理的问卷调查。采用多变量逻辑回归分析评估与 Mpox 疫苗接种相关的背景、Mpox 疾病特异性和 Mpox 疫苗特异性因素。报告调整后的优势比（aOR）和 95%置信区间（CI）。 结果：本研究中纳入的 SGM 参与者中，约有 50%至少接种了第一剂 Mpox 疫苗。多变量回归分析显示，最近经历过粮食不安全、因感染 Mpox 而产生更高程度的社会排斥恐惧、对 Mpox 疫苗更犹豫的个体更有可能未接种疫苗。相反，了解感染过 Mpox 的人、受教育程度更高、对与性有关的内化恐同现象程度更高、对因感染 Mpox 而导致的发病率更担心的个体更有可能接种两剂疫苗。 结论：本研究纳入的 SGM 参与者中，约有 50%至少接种了第一剂 Mpox 疫苗；然而，只有四分之一的参与者完成了推荐的 2 剂 Mpox 疫苗接种方案。我们的研究结果表明，社会经济稳定性、因疾病感染而产生的社会排斥恐惧以及 Mpox 特异性疫苗犹豫可能是在制定针对性少数群体需求的疫苗接种预防和干预策略时需要考虑的重要结构性目标。
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