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氧化应激相关糖尿病肾病的全球研究热点与趋势：一项文献计量学研究

Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study.

作者信息

Wang Xiao-Rong, Wu Zeng, He Tong-Tong, Chen Xiao-Han, Jin Xiao-Fei, Zuo Chun-Yue, Yang Shao-Ze, Gao Yu, Zhou Xiao-Hong, Gao Wei-Juan

机构信息

Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang, China.

出版信息

Front Endocrinol (Lausanne). 2025 Jan 10;15:1451954. doi: 10.3389/fendo.2024.1451954. eCollection 2024.

DOI:10.3389/fendo.2024.1451954
PMID:39866738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11757133/
Abstract

BACKGROUND: Oxidative stress is widely acknowledged as a key pathogenic mechanism in diabetic nephropathy (DN). In recent years, the role of oxidative stress in DN has garnered increasing attention. However, no bibliometric analysis has yet been conducted on the relationship between oxidative stress and DN. This study aims to systematically analyze the relevant literature, identify trends in research, assess current hotspots, and predict future directions. METHODS: We retrieved literature related to oxidative stress and DN from the Web of Science Core Collection database. We analyzed data on publication volume, countries/regions, institutions, journals, keywords, and other relevant metrics using VOSviewer, the Bibliometrix R package, and CiteSpace. RESULTS: From 2014 to 2024, a total of 4076 publications related to oxidative stress and DN were published across 755 journals, showing a consistent upward trend each year. China and the United States are the leading contributors in this field and demonstrate close collaborative efforts. The top contributors by country, institution, journal, and author include: China (1919 publications), Jilin University and Central South University (69 publications each), (117 publications), and Prof. Sun Lin (33 publications). The most frequent keyword is "oxidative stress" (3683 occurrences). In the co-citation analysis, Alicic RZ's 2017 study was the most cited (144 citations). These findings highlight the critical importance of investigating the pathogenesis of DN from the oxidative stress perspective. CONCLUSION: This study demonstrates a steady increase in research on oxidative stress in DN since 2014, highlighting its central role in the pathogenesis of DN. Future research should focus on the molecular mechanisms of oxidative stress in DN and explore its therapeutic potential, to provide new strategies for the prevention and treatment of DN.

摘要

背景：氧化应激被广泛认为是糖尿病肾病（DN）的关键致病机制。近年来，氧化应激在DN中的作用受到越来越多的关注。然而，尚未对氧化应激与DN之间的关系进行文献计量分析。本研究旨在系统分析相关文献，确定研究趋势，评估当前热点，并预测未来方向。 方法：我们从科学网核心合集数据库中检索了与氧化应激和DN相关的文献。我们使用VOSviewer、Bibliometrix R包和CiteSpace分析了关于出版物数量、国家/地区、机构、期刊、关键词和其他相关指标的数据。 结果：2014年至2024年，共有4076篇与氧化应激和DN相关的出版物发表在755种期刊上，每年呈持续上升趋势。中国和美国是该领域的主要贡献者，并展现出密切的合作努力。按国家、机构、期刊和作者划分的主要贡献者包括：中国（1919篇出版物）、吉林大学和中南大学（各69篇出版物）、（117篇出版物）以及孙林教授（33篇出版物）。最频繁出现的关键词是“氧化应激”（出现3683次）。在共被引分析中，阿利西奇·R·Z 2017年的研究被引用次数最多（144次）。这些发现凸显了从氧化应激角度研究DN发病机制的至关重要性。 结论：本研究表明自2014年以来关于DN中氧化应激的研究稳步增加，凸显了其在DN发病机制中的核心作用。未来的研究应聚焦于DN中氧化应激的分子机制，并探索其治疗潜力，以为DN的预防和治疗提供新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6017/11757133/2e464a8ed492/fendo-15-1451954-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6017/11757133/422e73c686ca/fendo-15-1451954-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6017/11757133/de8f435c9228/fendo-15-1451954-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6017/11757133/2e464a8ed492/fendo-15-1451954-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6017/11757133/422e73c686ca/fendo-15-1451954-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6017/11757133/de8f435c9228/fendo-15-1451954-g009.jpg
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Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study.

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本文引用的文献

[1]
Tiliroside protects against diabetic nephropathy in streptozotocin-induced diabetes rats by attenuating oxidative stress and inflammation.

World J Diabetes. 2024-11-15

[2]
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An and study.

World J Diabetes. 2024-10-15

[3]
Indoxyl Sulfate Aggravates Podocyte Damage through the TGF-β1/Smad/ROS Signalling Pathway.

Kidney Blood Press Res. 2024

[4]
Oxidative Stress: A Culprit in the Progression of Diabetic Kidney Disease.

Antioxidants (Basel). 2024-4-12

[5]
Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation.

Acta Pharm Sin B. 2024-4

[6]
Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway.

Phytomedicine. 2024-4

[7]
Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus.

Int J Mol Sci. 2023-12-12

[8]
The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy.

Int J Nephrol Renovasc Dis. 2023-12-5

[9]
Nanomedicines for the management of diabetic nephropathy: present progress and prospects.

Front Endocrinol (Lausanne). 2023

[10]
Biomarkers of Oxidative Stress in Diabetes Mellitus with Diabetic Nephropathy Complications.

Int J Mol Sci. 2023-8-31

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