Bjerregaard Caroline Løkke, Skaarup Kristoffer Grundtvig, Lassen Mats Christian Højbjerg, Biering-Sørensen Tor, Olsen Flemming Javier
Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, 2900 Hellerup, Denmark.
Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Diagnostics (Basel). 2023 May 17;13(10):1778. doi: 10.3390/diagnostics13101778.
Ventricular arrhythmia is one of the main causes of sudden cardiac death. Hence, identifying patients at risk of ventricular arrhythmias and sudden cardiac death is important but can be challenging. The indication for an implantable cardioverter defibrillator as a primary preventive strategy relies on the left ventricular ejection fraction as a measure of systolic function. However, ejection fraction is flawed by technical constraints and is an indirect measure of systolic function. There has, therefore, been an incentive to identify other markers to optimize the risk prediction of malignant arrhythmias to select proper candidates who could benefit from an implantable cardioverter defibrillator. Speckle-tracking echocardiography allows for a detailed assessment of cardiac mechanics, and strain imaging has repeatedly been shown to be a sensitive technique to identify systolic dysfunction unrecognized by ejection fraction. Several strain measures, including global longitudinal strain, regional strain, and mechanical dispersion, have consequently been proposed as potential markers of ventricular arrhythmias. In this review, we will provide an overview of the potential use of different strain measures in the context of ventricular arrhythmias.
室性心律失常是心源性猝死的主要原因之一。因此，识别有室性心律失常和心源性猝死风险的患者很重要，但也具有挑战性。植入式心脏复律除颤器作为一级预防策略的适应证依赖于左心室射血分数作为收缩功能的指标。然而，射血分数受技术限制存在缺陷，并且是收缩功能的间接指标。因此，人们一直有动力去识别其他标志物，以优化恶性心律失常的风险预测，从而选择能够从植入式心脏复律除颤器中获益的合适人选。斑点追踪超声心动图能够对心脏力学进行详细评估，并且应变成像已多次被证明是一种识别射血分数未发现的收缩功能障碍的敏感技术。因此，包括整体纵向应变、局部应变和机械离散度在内的几种应变测量方法已被提议作为室性心律失常的潜在标志物。在本综述中，我们将概述不同应变测量方法在室性心律失常背景下的潜在用途。
