压力-应变环分析得出的心肌做功指数的正常值：来自加拿大心血管健康研究。
Normal Values for Myocardial Work Indices Derived From Pressure-Strain Loop Analyses: From the CCHS.
机构信息
Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Hellerup, Denmark (F.J.O., K.G.S., M.C.H.L., N.D.J., M.S., G.G., T.B.-S.).
The Copenhagen City Heart Study, Copenhagen University Hospital-Frederiksberg and Bispebjerg Hospital, Denmark (F.J.O., K.G.S., M.C.H.L., N.D.J., M.S., G.B.J., P.S., J.L.M., T.B.-S.).
出版信息
Circ Cardiovasc Imaging. 2022 May;15(5):e013712. doi: 10.1161/CIRCIMAGING.121.013712. Epub 2022 May 10.
BACKGROUND
Pressure-strain loop analyses is a noninvasive technique capable of evaluating myocardial work. Reference values are needed to benchmark these myocardial work indices for clinical practice.
METHODS
Healthy participants from a general population study were used to establish reference values for global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) measured by pressure-strain loop analyses. The relation to age and sex was examined. We furthermore examined the proportion of abnormal work indices according to low, intermediate, and high cardiovascular risk by the Framingham risk score.
RESULTS
The healthy sample consisted of 1827 participants (median age, 45 years; 39% men). Lower reference values were GWI, 1576 mm Hg%; GCW, 1708 mm Hg%; and GWE, 93.0% and upper reference value for GWW was 159 mm Hg%. Women exhibited significantly higher GWI, GCW, and GWW and lower GWE. Sex significantly modified the association between all indices and age ( for interaction: 0.001 for GWI, 0.009 for GCW, 0.003 for GWW, and 0.009 for GWE). For men, only GCW increased with age, whereas the other indices did not change with age. For women, GCW increased linearly with increasing age, whereas GWI, GWW, and GWE changed in a curvilinear fashion with age such that GWI increased in younger participants, GWW increased in elderly, and GWE declined concordantly. Abnormalities in myocardial work indices became more frequent with increasing Framingham risk score category (abnormal GWI: 2% versus 4% versus 5%, =0.001; abnormal GCW: 2% versus 3% versus 4%, =0.006; abnormal GWW: 3% versus 6% versus 11%, <0.001; abnormal GWE: 3% versus 4% versus 11%, <0.001).
CONCLUSIONS
Myocardial work indices differ between sexes and change with age in a sex-dependent manner. Accordingly, we established age- and sex-specific reference values from a general population sample. Abnormal work indices become more frequent with higher clinical risk.
REGISTRATION
URL: https://www.
CLINICALTRIALS
gov; Unique identifier: NCT02993172.
背景
压力-应变环分析是一种能够评估心肌做功的非侵入性技术。需要参考值来为这些心肌工作指标在临床实践中提供基准。
方法
使用来自一般人群研究的健康参与者来建立整体工作指数（GWI）、整体建设性工作（GCW）、整体浪费工作（GWW）和压力-应变环分析测量的整体工作效率（GWE）的参考值。研究了它们与年龄和性别的关系。我们还根据弗雷明汉风险评分检查了异常工作指数在低、中、高心血管风险中的比例。
结果
健康样本由 1827 名参与者组成（中位数年龄 45 岁；39%为男性）。GWI、GCW 和 GWE 的参考值较低，分别为 1576mm Hg%、1708mm Hg%和 93.0%，而 GWW 的参考值较高为 159mm Hg%。女性的 GWI、GCW 和 GWW 显著较高，GWE 显著较低。性别显著改变了所有指标与年龄之间的关系（交互作用：GWI 为 0.001，GCW 为 0.009，GWW 为 0.003，GWE 为 0.009）。对于男性，只有 GCW 随年龄增长而增加，而其他指数与年龄无关。对于女性，GCW 随年龄呈线性增加，而 GWI、GWW 和 GWE 则呈曲线变化，即年轻参与者的 GWI 增加，老年参与者的 GWW 增加，而 GWE 则相应下降。随着弗雷明汉风险评分类别的增加，心肌工作指数的异常变得更加频繁（异常 GWI：2%比 4%比 5%，=0.001；异常 GCW：2%比 3%比 4%，=0.006；异常 GWW：3%比 6%比 11%，<0.001；异常 GWE：3%比 4%比 11%，<0.001）。
结论
心肌工作指数在性别之间存在差异，并以性别依赖的方式随年龄变化。因此，我们从一般人群样本中建立了年龄和性别特异性参考值。异常工作指数随着临床风险的增加而变得更加频繁。
注册
网址：https://www.
临床试验
gov；独特标识符：NCT02993172。
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