Messiah Sarah E, Swartz Michael D, Abbas Rhiana A, Talebi Yashar, Kohl Harold W, Valerio-Shewmaker Melissa, DeSantis Stacia M, Yaseen Ashraf, Kelder Steven H, Ross Jessica A, Padilla Lindsay N, Gonzalez Michael O, Wu Leqing, Lakey David, Shuford Jennifer A, Pont Stephen J, Boerwinkle Eric
Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health in Dallas, The University of Texas (UT) Health Science Center at Houston, Dallas, TX 77030, USA.
Center for Pediatric Population Health, UTHealth School of Public Health, Dallas, TX 75207, USA.
Children (Basel). 2023 Apr 30;10(5):818. doi: 10.3390/children10050818.
To describe COVID-19 illness characteristics, risk factors, and SARS-CoV-2 serostatus by variant time period in a large community-based pediatric sample.
Data were collected prospectively over four timepoints between October 2020 and November 2022 from a population-based cohort ages 5 to 19 years old.
State of Texas, USA.
Participants ages 5 to 19 years were recruited from large pediatric healthcare systems, Federally Qualified Healthcare Centers, urban and rural clinical practices, health insurance providers, and a social media campaign.
SARS-CoV-2 infection.
MAIN OUTCOME(S) AND MEASURE(S): SARS-CoV-2 antibody status was assessed by the Roche Elecsys Anti-SARS-CoV-2 Immunoassay for detection of antibodies to the SARS-CoV-2 nucleocapsid protein (Roche N-test). Self-reported antigen or PCR COVID-19 test results and symptom status were also collected.
Over half (57.2%) of the sample (N = 3911) was antibody positive. Symptomatic infection increased over time from 47.09% during the pre-Delta variant time period, to 76.95% during Delta, to 84.73% during Omicron, and to 94.79% during the Omicron BA.2. Those who were not vaccinated were more likely (OR 1.71, 95% CI 1.47, 2.00) to be infected versus those fully vaccinated.
Results show an increase in symptomatic COVID-19 infection among non-hospitalized children with each progressive variant over the past two years. Findings here support the public health guidance that eligible children should remain up to date with COVID-19 vaccinations.
在一个基于社区的大型儿科样本中，按变异株时期描述新冠病毒病（COVID-19）的疾病特征、危险因素和严重急性呼吸综合征冠状病毒2（SARS-CoV-2）血清学状态。
2020年10月至2022年11月期间，前瞻性地从4个时间点收集了基于人群的5至19岁队列的数据。
美国得克萨斯州。
5至19岁的参与者从大型儿科医疗系统、联邦合格医疗中心、城乡临床机构、健康保险提供商以及一场社交媒体活动中招募。
SARS-CoV-2感染。
采用罗氏电化学发光法抗SARS-CoV-2免疫测定法检测SARS-CoV-2抗体状态，以检测针对SARS-CoV-2核衣壳蛋白的抗体（罗氏N检测）。还收集了自我报告的抗原或PCR新冠病毒检测结果以及症状状态。
样本（N = 3911）中超过一半（57.2%）抗体呈阳性。有症状感染随时间增加，从德尔塔变异株出现前时期的47.09%，增至德尔塔变异株时期的7%，再增至奥密克戎变异株时期的84.73%，以及奥密克戎BA.2变异株时期的94.79%。未接种疫苗者比完全接种疫苗者更易感染（比值比1.71，95%置信区间1.47，2.00）。
结果显示，在过去两年中，随着每一个变异株的出现，非住院儿童中出现症状的新冠病毒感染有所增加。此处的研究结果支持公共卫生指导意见，即符合条件的儿童应及时接种新冠病毒疫苗。
