Neuromuscular Plasticity Laboratory, Institute of Exercise Physiology and Rehabilitation Science, School of Kinesiology and Physical Therapy, University of Central Florida, Orlando, FL 32816, USA.
Physiology of Work and Exercise Response (POWER) Laboratory, Institute of Exercise Physiology and Rehabilitation Science, School of Kinesiology and Physical Therapy, University of Central Florida, Orlando, FL 32816, USA.
Nutrients. 2021 May 27;13(6):1825. doi: 10.3390/nu13061825.
Numerous health conditions affecting the musculoskeletal, cardiopulmonary, and nervous systems can result in physical dysfunction, impaired performance, muscle weakness, and disuse-induced atrophy. Due to its well-documented anabolic potential, creatine monohydrate has been investigated as a supplemental agent to mitigate the loss of muscle mass and function in a variety of acute and chronic conditions. A review of the literature was conducted to assess the current state of knowledge regarding the effects of creatine supplementation on rehabilitation from immobilization and injury, neurodegenerative diseases, cardiopulmonary disease, and other muscular disorders. Several of the findings are encouraging, showcasing creatine's potential efficacy as a supplemental agent via preservation of muscle mass, strength, and physical function; however, the results are not consistent. For multiple diseases, only a few creatine studies with small sample sizes have been published, making it difficult to draw definitive conclusions. Rationale for discordant findings is further complicated by differences in disease pathologies, intervention protocols, creatine dosing and duration, and patient population. While creatine supplementation demonstrates promise as a therapeutic aid, more research is needed to fill gaps in knowledge within medical rehabilitation.
许多影响肌肉骨骼、心肺和神经系统的健康状况可导致身体功能障碍、表现受损、肌肉无力和废用性萎缩。由于肌酸一水合物具有良好的记载的合成代谢潜力，因此已将其作为一种补充剂进行研究，以减轻各种急性和慢性疾病中肌肉质量和功能的丧失。本文对文献进行了综述，以评估关于肌酸补充对固定和损伤、神经退行性疾病、心肺疾病和其他肌肉疾病康复的影响的现有知识状况。一些研究结果令人鼓舞，展示了肌酸作为补充剂通过保存肌肉质量、力量和身体功能的潜在功效；然而，结果并不一致。对于多种疾病，只有少数关于肌酸的研究具有较小的样本量，因此难以得出明确的结论。由于疾病病理、干预方案、肌酸剂量和持续时间以及患者人群的差异，导致不一致发现的理由进一步复杂化。虽然肌酸补充作为一种治疗辅助手段具有潜力，但仍需要更多的研究来填补医学康复领域知识空白。
