Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France.
AP-HP, Hôpitaux Universitaires Henri Mondor, Service de Néphrologie, F-94010 Creteil, France.
Biomolecules. 2023 May 12;13(5):827. doi: 10.3390/biom13050827.
Glycosphingolipids comprise a lipid class characterized by the presence of sugar moieties attached to a ceramide backbone. The role of glycosphingolipids in pathophysiology has gained relevance in recent years in parallel with the development of analytical technologies. Within this vast family of molecules, gangliosides modified by acetylation represent a minority. Described for the first time in the 1980s, their relation to pathologies has resulted in increased interest in their function in normal and diseased cells. This review presents the state of the art on 9-O acetylated gangliosides and their link to cellular disorders.
糖脂由糖链连接到神经酰胺骨架上组成，属于脂质的一种。近年来，随着分析技术的发展，糖脂在病理生理学中的作用受到了广泛关注。在这个庞大的分子家族中，经乙酰化修饰的神经节苷脂是少数。这些物质于 20 世纪 80 年代首次被描述，其与疾病的关系引起了人们对其在正常和病变细胞中功能的兴趣。本综述介绍了 9-O 乙酰化神经节苷脂的最新研究进展及其与细胞紊乱的关系。
